Characterization of DNA-Linked Nanoparticle Networks for Advanced Genetic Testing

新墨西哥州立大学的Joseph Wang教授得到了分析和表面化学项目的支持，研究用作传感器的纳米粒子-生物聚合物组件。特别是，DNA杂交事件将在金纳米粒子上电检测，最终应用于生物诊断和生物检测。结合多种扩增途径和有效磁分离的新检测方法将增加传感器的选择性和灵敏度。将开发一种新的电化学编码技术，用于同时检测多个DNA靶点。这些项目将在微流控设备平台上结合。将复杂的化学功能小型化以实现芯片实验室是纳米技术的一个目标。此外，这项工作可能与生物战探测有关，因此对国家安全有影响。

Professor Joseph Wang of New Mexico State University is supported by the Analytical and Surface Chemistry Program to study nanoparticle-biopolymer assemblies for use as sensors. In particular, DNA hybridization events will be detected electrically on gold nanoparticles, with eventual applications in biodiagnostics and biodetection. New assays that couple multiple amplification pathways and an effective magnetic separation will allow for increased selectivity and sensitivity in the sensors. A new electrochemical coding technology will be developed for the simultaneous detection of multiple DNA targets. These projects will be combined on microfluidic device platforms. The ability to miniaturize complex chemical functions to achieve lab-on-a-chip is a goal of nanotechnology. In addition, this work can be related to biowarfare detection and thus has implications for national security.