Organosulfur Natural Products Chemistry

该项目将探索天然来源的不寻常有机硫化合物的化学性质。首先，将从非洲、南美和中东的多种葱属植物（大蒜和洋葱）中分离、鉴定和表征新的有机硫化合物。然后将对这些新的有机硫化合物的合成和有机反应化学进行研究。天然产物的热分解也将被研究，因为这项研究将与烹饪时植物成分的命运有关。有机和大分子化学项目通过这项少数民族研究计划资助奖，支持纽约州立大学奥尔巴尼分校化学系Rabi A. Musah博士的研究。Musah博士将致力于从非洲、南美和中东的各种葱属植物（大蒜和洋葱）中分离、鉴定和表征新的有机硫化合物。然后对这些新的有机硫化合物的合成和有机反应化学进行研究。天然产物的热分解也将被研究，因为这项研究将与烹饪时植物成分的命运有关。已知葱属中的其他植物含有具有大量生物医学应用的化合物，因此这项工作很有可能会发现具有生物活性的新化合物。在此工作过程中训练的学生将获得特种化学品和制药行业所需的技能。

This project will explore the chemistry of unusual organosulfur compounds of natural origin. Initially, new organosulfur compounds from a variety of plants in the allium (garlic and onion) genus from Africa, South America and the Middle East will be isolated, identified and characterized. Synthesis and study of the organic reaction chemistry of these new organosulfur compounds will then be investigated. Thermal decomposition of the natural products will also be studied since this study will be relevant to the fate of the plant constituents upon cooking.With this Minority Research Planning Grant award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Rabi A. Musah of the Department of Chemistry at the State University of New York at Albany. Dr. Musah will work on the isolation, identification, and characterization of new organosulfur compounds from a variety of plants in the allium (garlic and onion) genus from Africa, South America and the Middle East. The synthesis and study of the organic reaction chemistry of these new organosulfur compounds will then be investigated. Thermal decomposition of the natural products will also be studied since this study will be relevant to the fate of the plant constituents upon cooking. Other plants within the allium genus are known to contain compounds with a host of biomedical science applications so there is a high probability that new compounds with biological activities will be discovered as a result of this work. Students trained during the course of this work will gain skills needed by the speciality chemicals and pharmaceutical industries.