CAREER: Organosulfur Natural Products Chemistry

职业：有机硫天然产物化学

• 批准号: 0239755
• 负责人: Rabi Musah
• 金额: $ 50.23万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239755&HistoricalAwards=false
• 关键词: CAREER; Organosulfur; Natural; Products; Chemistry

This research program focuses on the organosulfur chemistry of natural products isolated from plants with insecticidal, agricultural, or medicinal value, and whose organoleptic properties imply the presence of organosulfur derivatives other than the ubiquitous sulfur containing compounds such as cysteine and methionine. Major objectives include 1) isolation and characterization of novel potentially useful gamma-glutamyl cysteines, 2) C-S lyase crystallization, structure determination, and mechanistic study, 3) assessment of the variety of cysteine sulfoxide precursors responsible for organosulfur headspace volatiles observed in selected plants, 4) chemotaxonomic classification of plant species, 5) determination of the lachrymatory principle(s) in plants, 6) thiosulfinate chemistry and optical activity, 7) determination of formation pathways of observed organosulfur natural products, and 8) synthesis and characterization of observed novel compounds. A three-pronged approach to integrate teaching and education will be taken, involving a K-12 scientific outreach program, mentorship at the undergraduate and graduate levels, and pedagogical innovations in teaching and research.With the support of this CAREER Award from the Organic and Macromolecular Chemistry Program, Professor Rabi Musah, of the Department of Chemistry at the State University of New York, Albany, is exploring the chemistry of sulfur-containing natural products. Garlic is the best-characterized organosulfur containing plant. It has become increasingly evident that other plants possess considerably different organosulfur chemical makeups. Given the rich diversity of compounds and chemistry observed in garlic and onions, it is likely that numerous other novel compounds with interesting and important chemical and biological properties are present in other plants. Through a variety of integrated approaches, Professor Musah will explore the isolation, characterization, and attendant chemistry and biochemistry of organosulfur products from natural sources. In addition, Professor Musah will develop a K-12 scientific outreach program and implement a mentorship program at the undergraduate and graduate levels.

本研究项目侧重于从具有杀虫、农业或药用价值的植物中分离出的天然产物的有机硫化学，其感官特性意味着有机硫衍生物的存在，而不是普遍存在的含硫化合物，如半胱氨酸和蛋氨酸。主要目标包括1)分离和表征新的潜在有用的γ -谷氨酰基半胱氨酸，2)C-S裂解酶结晶，结构测定和机制研究，3)评估在选定植物中观察到的负责有机硫顶空挥发物的半胱氨酸亚砜前体的多样性，4)植物物种的化学分类分类，5)确定植物的泻药原理，6)硫代亚硫酸盐化学和光学活性，7)确定观察到的有机硫天然产物的形成途径，8)合成和表征观察到的新化合物。将采取三管齐下的方法来整合教学和教育，包括K-12科学推广计划，本科和研究生水平的指导，以及教学和研究的教学创新。在有机和大分子化学项目的CAREER奖的支持下，纽约州立大学奥尔巴尼分校化学系的Rabi Musah教授正在探索含硫天然产物的化学性质。大蒜是最具特征的有机含硫植物。越来越明显的是，其他植物具有相当不同的有机硫化学组成。鉴于在大蒜和洋葱中观察到的化合物和化学成分的丰富多样性，很可能在其他植物中存在许多具有有趣和重要的化学和生物学特性的新化合物。通过多种综合方法，Musah教授将探索天然来源有机硫产品的分离，表征以及随之而来的化学和生物化学。此外，Musah教授将开发一项K-12科学推广计划，并在本科和研究生阶段实施指导计划。