MRI: Acquisition of a 500 MHz NMR Spectrometer for Research and Training

MRI：购买 500 MHz NMR 波谱仪用于研究和培训

• 批准号: 1726724
• 负责人: Rabi Musah
• 金额: $ 50万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726724&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; NMR

This award is supported by the Major Research Instrumentation Program (MRI) and the Chemistry Research Instrumentation Program (CRIF). With it, Professor Rabi Musah from SUNY Albany and colleagues acquired a 500 MHz nuclear magnetic resonance (NMR) spectrometer. A NMR spectrometer measures weak signals from atomic nuclei in a sample when stimulated by light. These signals enable identification of the atoms (for example, hydrogen, carbon, and other elements) in the chemical or material under study. NMR is a powerful analytical technique used to characterize reaction products, proteins and other biological species, or unknown substances which need to be identified. Consequently, NMR spectrometers are essential to chemistry, biological and environmental research. The instrument is used to train students in the technique preparing them for their careers. The spectrometer is a resource available to other institutions in the greater Albany region including the College of St. Rose and Skidmore College. The award of the NMR spectrometer is aimed at enhancing research and education at all levels. This instrument may impact studies synthesizing and characterizing organosulfur and organoselenium compounds, and organosulfur natural products such as plant chemical defense molecules. The instrument is used for investigating heterometallic molecular precursors for the preparation of energy-related materials. Research on carbon-rich pi-bowls, nanobelts and warped nanographene sheets advance with data from the instrument. The spectrometer is an integral tool in several projects exploring the syntheses of biologically active species. These include synthetic approaches to small-molecule peptide natural products, and the chemical synthesis of peptides, proteins and glycoproteins. Also under investigation are the synthesis of naturally modified RNA nucleosides, nucleotides and oligonucleotides and the determination of their crystal structures.

该奖项由主要研究仪器计划（MRI）和化学研究仪器计划（CRIF）支持。有了它，纽约州立大学奥尔巴尼分校的Rabi Musah教授和他的同事们获得了一台500兆赫的核磁共振（NMR）光谱仪。核磁共振波谱仪测量样品中受光刺激时原子核发出的微弱信号。这些信号能够识别所研究的化学物质或材料中的原子（例如氢、碳和其他元素）。核磁共振是一种强大的分析技术，用于表征反应产物，蛋白质和其他生物物种，或需要鉴定的未知物质。因此，核磁共振光谱仪在化学、生物和环境研究中是必不可少的。这种乐器是用来训练学生的技术，为他们的职业生涯做准备。该光谱仪是大奥尔巴尼地区其他机构可利用的资源，包括圣罗斯学院和斯基德莫尔学院。核磁共振光谱仪的奖励旨在加强各级的研究和教育。该仪器将影响有机硫、有机硒化合物的合成和表征，以及有机硫天然产物如植物化学防御分子的研究。该仪器用于研究制备能源相关材料的异质金属分子前体。富碳pi-bowl，纳米带和翘曲纳米石墨烯片的研究随着仪器的数据而推进。光谱仪是探索生物活性物种合成的几个项目中不可或缺的工具。其中包括小分子多肽天然产物的合成方法，以及多肽、蛋白质和糖蛋白的化学合成。研究还包括自然修饰RNA核苷、核苷酸和寡核苷酸的合成及其晶体结构的测定。

项目成果

Oxidative phenol-arene and phenol-phenol cross-coupling using periodic acid

• DOI: 10.1016/j.tet.2019.02.021
• 发表时间: 2019-03-29
• 期刊: TETRAHEDRON
• 影响因子: 2.1
• 作者: Gao, Peng-Cheng;Chen, Huan;Zhang, Qiang
• 通讯作者: Zhang, Qiang

Multiple C−H Bond Activations in Corannulene by a Dirhenium Complex

二铼络合物对 Corannulene 中的多个 C–H 键激活

• DOI: 10.1002/chem.201806405
• 发表时间: 2019
• 期刊: Chemistry – A European Journal
• 作者: Adams, Richard D.;Dhull, Poonam;Pennachio, Matthew;Petrukhina, Marina A.;Smith, Mark D.
• 通讯作者: Smith, Mark D.

Understanding Polyarene Trifluoromethylation with Hot CF 3 Radicals Using Corannulene: Understanding Polyarene Trifluoromethylation with Hot CF 3 Radicals Using Corannulene

了解使用 Corannulene 的热 CF 3 自由基的聚芳烃三氟甲基化：了解使用 Corannulene 的热 CF 3 自由基的聚芳烃三氟甲基化

• DOI: 10.1002/ejoc.201800508
• 发表时间: 2018
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Kuvychko, Igor V.;Clikeman, Tyler;Dubceac, Cristina;Chen, Yu-Sheng;Petrukhina, Marina A.;Strauss, Steven H.;Popov, Alexey A.;Boltalina, Olga V.
• 通讯作者: Boltalina, Olga V.

Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections

• DOI: 10.1021/acscentsci.8b00344
• 发表时间: 2018-12-26
• 期刊: ACS CENTRAL SCIENCE
• 影响因子: 18.2
• 作者: Czuban, Magdalena;Srinivasan, Sangeetha;Oneto, Jose M. Mejia
• 通讯作者: Oneto, Jose M. Mejia

Dimerization of indenocorannulene radicals: imposing stability through increasing strain and curvature

茚并环烯自由基的二聚化：通过增加应变和曲率来增强稳定性

• DOI: 10.1039/d0qo00686f
• 发表时间: 2020
• 期刊: Organic Chemistry Frontiers
• 影响因子: 5.4
• 作者: Rogachev, Andrey Yu.;Zhu, Yikun;Zhou, Zheng;Liu, Shuyang;Wei, Zheng;Petrukhina, Marina A.
• 通讯作者: Petrukhina, Marina A.