SBIR Phase II: Comprehensive Database Resource on Protein Localization

这个小型企业创新研究（SBIR）第二阶段项目建议开发数据库和相关软件，以分析蛋白质运输和定位。该系统的设计将使药物发现研究人员能够识别，阐明，消除和设计线索和目标，同时促进研究人员的一般培训。在第一阶段的工作中，参与贩运的蛋白质和与错误定位有关的疾病被确定，并建立了一个关系数据库，以容纳有关蛋白质贩运的信息。创建了管理界面应用程序，以允许远程数据输入，并设计了图形用户界面，以最大限度地利用信息。 第二阶段项目的目标是从主要期刊文献中详尽地填充数据库。参与蛋白质运输的蛋白质的选择将由相关的人类疾病和相应的药物发现工作指导。该项目的商业应用是在生物信息学领域。本项目拟开发的生物数据库的潜在用户将包括制药和药物发现公司。

This Small Business Innovation Research (SBIR) Phase II Project proposes to develop the database and associated software to enable analysis of protein trafficking and localization. The system will be designed to enable drug discovery researchers to identify, elucidate, eliminate and design leads and targets, while facilitating the general training of researchers. During the Phase I work, proteins involved in trafficking and diseases related to mislocalization were identified, and a relational database to house information on protein trafficking was constructed. Curation interface applications were created to allow remote data entry, and graphical user interfaces designed to maximize the utility of the information. The objective of this Phase II Project is to exhaustively populate the database from the primary journal literature. Selection of proteins involved in protein trafficking will be guided by relevant human diseases and corresponding drug discovery efforts. The commercial application of this project is in the area of biological informatics. The potential users of the biological database to be developed in this project would include pharmaceutical and drug discovery companies.