Position and Orientation Specific Immobilization of Antibodies via Nanofabrication and Polyvalent Interactions

加州戴维斯大学的刘刚宇教授得到了分析和表面化学项目的支持，以制造纳米结构，使抗体与指定位置结合，同时保持其生物活性。 扫描探针尖端用于固定抗原，然后与抗体进行二价结合。 用扫描探针显微镜（SPM）探测结构。 这些组装体能否触发模仿自然免疫过程的细胞反应？这些研究有可能在生物分析和生物工程领域开辟新的研究途径。 该项目还涉及到将生物传感器等电子产品的分子尺度化的目标。 学生接受电化学和纳米纤维技能的跨学科培训，并受益于与合成化学家和免疫学家的密切合作。

Professor Gang-Yu Liu of the University of California Davis is supported by the Analytical and Surface Chemistry program to fabricate nanostructures that immobilize antibodies with designated positions while maintaining their bioreactivity. Scanning probe tips are used to secure antigens followed by divalent binding of antibodies. The structures are probed by scanning probe microscopy (SPM). Can the assemblies trigger cell responses which mimic natural immune processes? These studies have the potential to open new avenues of study in bioanalytical and bioengineering areas. The project also relates to the goals of miniaturizing electronics such as biosensors to molecular-size scale. Students receive interdisciplinary training in electrochemistry and nanofabrication skills and benefit from close collaboration with a synthetic chemist and an immunologist.