CAREER: Development of Nanofabrication Techniques for Self-assembled Monolayer Based Biosensors

这项由分析和表面化学计划支持的学院早期职业发展(CALEAR)项目，重点是使用刘教授和她在韦恩州立大学的学生开发的新技术来非常精确地修饰包含自组装单层的表面。正在开发改进方法，以便能够研究生物识别过程，并利用其特异性在非常小(亚微米)的尺度上开发新型化学传感器。这一职业研究项目还包括在研究生和本科生课程中引入新的表面化学课程和实验室。刘教授和她的学生参加了一门名为《智能传感器和智能设备》的新颖课程，这将增强这种跨学科研究的可能结果。先进的材料加工方法和不断扩大的分子生物学领域的结合具有广泛的意义。刘教授和她在韦恩州立大学的学生们开发了微制造方法，这些方法为组装设备带来了巨大的希望，这些设备可以研究生物识别过程，从而进一步用于创造极高特异性的传感器设备。可以预见，这种研究的成果将延伸到新一代环境和生物监测仪。刘教授将传感器开发课程的跨学科性质扩展到研究生和本科课程，向她的学生介绍关于化学研究的新思维方式。

This Faculty Early Career Development (CAREER) project, supported in the Analytical and Surface Chemistry Program, focuses on the use of new technology developed by Professor Liu and her students at Wayne State University to very precisely modify surfaces incorporating self-assembled monolayers. Modification methods are being developed to allow the study of biorecognition processes and to use their specificity to develop new types of chemical sensors on very small (sub-micrometer) scales. This CAREER research project also involves the introduction of new surface chemistry courses and laboratories into the graduate and undergraduate curricula. Participation in a novel `Smart Sensor and Intelligent Devices`course by Professor Liu and her students will enhance the possible outcomes of this sort of interdisciplinary research. The integration of advanced materials processing methods and the expanding field of molecular biology has broadranging implications. Professor Liu and her students at Wayne State University have developed microfabrication methodologies which hold great promise for the assembly of devices which allow for the study of biorecognition processes which can be further utilized for the creation of sensor devices of extremely high specificity. The outcome of such research can be envisioned to extend to a new generation of environmental and biological monitors. Professor Liu extends the interdisciplinary nature of sensor development program to the graduate and undergraduate curricula to introduce her students to new ways of thinking about chemical research.