CAREER: Development of Nanofabrication Techniques for Self-assembled Monolayer Based Biosensors

职业：自组装单层生物传感器纳米制造技术的开发

• 批准号: 9733400
• 负责人: Gang-Yu Liu
• 金额: $ 27.5万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-15 至 2002-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9733400&HistoricalAwards=false
• 关键词: CAREER; Development; Nanofabrication; Techniques; Self

This Faculty Early Career Development (CAREER) project, supported in the Analytical and Surface Chemistry Program, focuses on the use of new technology developed by Professor Liu and her students at Wayne State University to very precisely modify surfaces incorporating self-assembled monolayers. Modification methods are being developed to allow the study of biorecognition processes and to use their specificity to develop new types of chemical sensors on very small (sub-micrometer) scales. This CAREER research project also involves the introduction of new surface chemistry courses and laboratories into the graduate and undergraduate curricula. Participation in a novel `Smart Sensor and Intelligent Devices`course by Professor Liu and her students will enhance the possible outcomes of this sort of interdisciplinary research. The integration of advanced materials processing methods and the expanding field of molecular biology has broadranging implications. Professor Liu and her students at Wayne State University have developed microfabrication methodologies which hold great promise for the assembly of devices which allow for the study of biorecognition processes which can be further utilized for the creation of sensor devices of extremely high specificity. The outcome of such research can be envisioned to extend to a new generation of environmental and biological monitors. Professor Liu extends the interdisciplinary nature of sensor development program to the graduate and undergraduate curricula to introduce her students to new ways of thinking about chemical research.

这个由分析和表面化学项目支持的教师早期职业发展（Career）项目，侧重于使用由韦恩州立大学Liu教授和她的学生开发的新技术来非常精确地修饰含有自组装单层的表面。正在开发修改方法，以便研究生物识别过程，并利用其特异性开发非常小（亚微米）尺度的新型化学传感器。CAREER研究项目还包括在研究生和本科生课程中引入新的表面化学课程和实验室。刘教授和她的学生参与一门新颖的“智能传感器和智能设备”课程，将加强这类跨学科研究的可能成果。先进的材料加工方法与分子生物学不断扩大的领域相结合具有广泛的意义。刘教授和她在韦恩州立大学的学生已经开发出了微制造方法，这种方法对设备的组装有很大的希望，可以研究生物识别过程，并进一步用于制造具有极高特异性的传感器设备。可以设想，这种研究的结果将扩展到新一代的环境和生物监测仪。刘教授将传感器开发项目的跨学科性质扩展到研究生和本科生课程中，向学生介绍化学研究的新思路。