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Controlled Molecular Assembly for 3D Nanoprinting

用于 3D 纳米打印的受控分子组装

基本信息

批准号：
1808829
负责人：
Gang-Yu Liu
金额：
$ 48万
依托单位：
University of California-Davis
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1808829&HistoricalAwards=false
关键词：
Controlled Molecular Assembly 3D Nanoprinting

项目摘要

Professor Gang-Yu Liu of the University of California Davis is supported by the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program of the Division of Chemistry to further miniaturize three-dimensional (3D) printing technology from its current minimum feature size of about 0.3 micrometer to less than 0.1 micrometer (100 nanometer), which is a tiny fraction (less than 1/100,000) of the thickness of a human hair. While 3D printing at the macro- and micro-scale is relatively mature, achieving nanometer feature size and precision is still a challenge. To address this, the project tackles two fundamental issues: (a) how to deliver ultra-small amounts of material; and (b) how to deliver the materials to the designed location with nanometer precision. The project advances a new approach with novel chemistry concepts for the assembly of molecules into 3D nanostructures by design. This approach may bring us closer to achieving controlled physical and chemical properties by controlling how the molecules are put together. This project broadens the application of 3D printing in diverse fields, such as in nanotechnology, nanodevices and sensors, tissue engineering, and in biochemistry and biomedical research. It also boosts the capability of additive manufacturing down to the nanometer scale and consequently enhances the competitive edge of the United States 3D printing industry. Graduate students are trained in research methods at the forefront of nanotechnology and additive manufacturing. Professor Liu continues her long-term collaborations with local community colleges and her international education and outreach activities. The outreach activities include summer research opportunities and seminars to stimulate the interest of a diverse group of students in advanced chemistry education and to increase awareness of 3D printing and its societal benefits.The project focuses on controlling the assembly of polymer molecules by direct writing of solutions containing designated components. To achieve molecular level control, a state-of-the-art atomic force microscope is interfaced with a nanofluidic delivery system. The former is an existing technology for high-resolution imaging with nanometer precision, and the latter can be considered as an ultra-small needle (opening as small as 30 nm). The research team has recently improved the delivery of femtoliter droplets, and prior work and preliminary data have demonstrated the feasibility of assembly at the microscale level. The project builds on this foundation. The aim is to reduce the droplet size down to the sub-attoliter level. Towards this end, contact time, pressure and the hydrophobicity of surfaces are modified to weaken inter-molecular and molecule-surface interactions and consequently enhance the kinetics of the assembly process. Long-term collaborations with local community colleges continue with the designed research project, summer research program, seminar and educational activities. These activities attract a more diverse population of students into advanced chemistry education. International research and education activities keep the team well informed and updated in the field of atomic force microscopy and3D printing research and development efforts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

加州戴维斯大学的刘刚宇教授得到化学系大分子、超分子和纳米化学（MSN）项目的支持，进一步将三维（3D）打印技术从目前的最小特征尺寸约0.3微米提高到小于0.1微米（100纳米），这是人类头发厚度的一小部分（小于1/100，000）。虽然宏观和微观尺度的3D打印相对成熟，但实现纳米特征尺寸和精度仍然是一个挑战。为了解决这个问题，该项目解决了两个基本问题：（a）如何提供超少量的材料;（B）如何将材料以纳米精度提供到设计位置。该项目提出了一种新的化学概念，通过设计将分子组装成3D纳米结构。这种方法可以使我们更接近通过控制分子如何组合在一起来实现受控的物理和化学性质。该项目拓宽了3D打印在不同领域的应用，如纳米技术、纳米器件和传感器、组织工程以及生物化学和生物医学研究。它还将增材制造的能力提高到纳米级，从而增强了美国3D打印行业的竞争优势。研究生在纳米技术和增材制造的最前沿的研究方法进行培训。刘教授继续她与当地社区学院的长期合作，以及她的国际教育和外展活动。该项目的推广活动包括暑期研究机会和研讨会，以激发不同群体的学生对高级化学教育的兴趣，并提高对3D打印及其社会效益的认识。该项目的重点是通过直接写入含有指定成分的溶液来控制聚合物分子的组装。为了实现分子水平的控制，一个国家的最先进的原子力显微镜接口与纳米流体输送系统。前者是现有的纳米精度高分辨率成像技术，后者可以被认为是超小针（开口小至30 nm）。研究小组最近改进了飞升液滴的输送，先前的工作和初步数据已经证明了在微尺度水平上组装的可行性。该项目建立在这个基础上。目的是将液滴尺寸减小到亚阿升水平。为此，接触时间，压力和表面的疏水性被修改，以削弱分子间和分子-表面相互作用，从而增强组装过程的动力学。与当地社区学院的长期合作继续与设计的研究项目，夏季研究计划，研讨会和教育活动。这些活动吸引了更多样化的学生进入高级化学教育。国际研究和教育活动使该团队在原子力显微镜和3D打印研究和开发工作领域获得了充分的信息和更新。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Controlled Molecular Assembly via Dynamic Confinement of Solvent

通过溶剂的动态限制控制分子组装

DOI：
10.1021/acs.jpclett.8b02442
发表时间：
2018
期刊：
The Journal of Physical Chemistry Letters
影响因子：
0
作者：
Zhang, Jiali;Piunova, Victoria A.;Liu, Yang;Tek, Andy;Yang, Qingbo;Frommer, Jane;Liu, Gang-yu;Sly, Joseph
通讯作者：
Sly, Joseph

Daylight-Active Cellulose Nanocrystals Containing Anthraquinone Structures

含有蒽醌结构的日光活性纤维素纳米晶体