NER: Nanofluidics for Advanced Separation and Detection of Biomolecules

提案标题：NER：Nanofluidics for Advanced Separation and Detection of Biomolecules提案号：CTS-0304237首席研究员：Sang HanInstitution：University of New Mexico该项目的目标是制造用于高通量生物分析的通用混合微流体系统。 将进行纳米结构中生物分子传输的实验研究，包括纳米结构中电泳力和熵力的影响。 所设想的分析系统由用于生物分离的纳米通道、用于分析物递送和回收的外围微通道以及集成光学检测系统组成。 检测系统包括荧光光谱、表面增强拉曼光谱和多次内反射傅里叶变换红外光谱。 在更广泛的影响方面，PI将帮助开发光学，光谱成像和生物传感课程。 计划对高中和代表性不足的群体进行宣传。 纳米加工的波导可以为许多生物技术应用提供检测生物分子的卓越灵敏度。 该项目由热传输和热处理项目共同资助。

Proposal Title: NER: Nanofluidics for Advanced Separation and Detection of BiomoleculesProposal Number: CTS-0304237Principal Investigator: Sang HanInstitution: University of New MexicoThe objective of the project is to fabricate versatile, hybrid microfluidic systems for high throughput bioanalysis. An experimental study of biomolecular transport in nanoscale structures, including the effects of electrophoretic and entropic forces in nanostructures will be performed. The envisioned analytical system consists of nanochannels for bioseparation, peripheral microchannels for analyte delivery and recovery, and an integrated optical detection system. The detection system includes fluorescence spectroscopy, surface enhanced Raman spectroscopy, and multiple internal reflection Fourier transform infrared spectroscopy. In terms of the broader impacts, the PIs will help develop courses in optics, spectroscopic imaging, and biosensing. Outreach to high schools and underrepresented groups is planned. The nanomachined waveguides may provide exceptional sensitivity to detect biomolecules for numerous biotechnology applications. This project is co-funded by the Thermal Transport and Thermal Processing Program.