Catalytic Methods for C-C Bond-Forming Reactions

本研究的重点是发展催化的、立体选择性的碳-碳键形成反应。将合成新的不对称催化配体，并进行典型的乙烯基芳烃、双烯和张力烯烃的氢乙烯基化反应。此外，还将探索包括二烯和张力烯烃在内的杂二聚化，目标是解决外环立体化学问题和钯催化的X-Y介导的二炔、烯丙炔和烯丙醛的环化反应([X-Y]=[硅-锡]，[硼-锡]，[锡-锡])环化应用。RajanBabu教授将重点开发在合成化学中间体的催化过程中使用大量可用的碳源的方法。将研究商业上相关的乙烯基芳烃以及双烯和张力烯烃的氢乙烯基化反应。该方法的实用性将通过合成几个生物活性靶标的制备来展示。该项目对制药和农业产生了更广泛的影响，并为研究生的培养提供了良好的环境。

The focus of this research involves the development of catalytic, stereoselective carbon-carbon bond forming reactions. New ligands for asymmetric catalysis will be synthesized and hydrovinylation of prototypical vinylarenes, dienes and strained olefins will be carried out. Further, heterodimerizations including dienes and strained olefins will be probed with the goal of solving the problem of exocyclic stereochemistry and applications of palladium-catalyzed, X-Y-mediated ([X-Y] = [Si-Sn], [B-Sn], [Sn-Sn]) cyclization of diynes, alleneynes and allenylaldehydes will be provided for the stereoselective synthesis of carbocyclic and heterocyclic compounds.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thaliyil V. RajanBabu in the Department of Chemistry at the Ohio State University. Professor RajanBabu will focus on developing methodology for using abundantly available carbon sources in the catalytic processes for the synthesis of chemical intermediates. The hydrovinylation of commercially relevant vinylarenes as well as dienes and strained olefins will be studied. The utility of the approach will be showcased by the preparation of synthesis of several biologically active targets. The project has broader impacts for the pharmaceutical and agricultural industries and provides an excellent climate for the training of graduate students.