The neural correlates of social-communicative perception in patients with schizophrenia, major depression und bipolar disorder: Disorder specific and disorder-unspecific aspects of the comprehension, recognition and interpretation of verbal and non-verbal

精神分裂症(SZ)、抑郁症(MD)和双相情感障碍(BD)患者的特点是多模式语义和社会认知沟通过程的障碍。这些功能障碍和相关神经相关因素的疾病和症状特异性和跨诊断价值尚不清楚。在拟议的项目中，社会交际功能的三个重要层面(见Ochsner，2008；Biol.在第一个资助期(DFG GZ：KI 588/6-1)，我们可以证明，在精神分裂症患者中，偏执、混乱和消极综合征与知觉和社会情绪脑区的激活有特异性的关联，不同于Ochsners的三个结构。到目前为止，已经收集和分析了所有数据。已经发表了九篇同行评议的研究文章，目前正在筹备另外七份出版物。已完成四篇学士学位论文和两篇硕士学位论文。A.在该项目中担任博士后的Nagels可以完成他的康复治疗，首席研究员B.Straube被任命为DFG Heisenberg教授。在拟议的项目中，将包括60名DSM IV SZ、MD、BD患者和健康对照组。通过SAPS/SANS、HAMD和YMRS，将执行症状特征(偏执、无组织、阴性、躁狂、抑郁)。受试者将接受三种功能磁共振成像范式的检查，每一种范式都反映了Ochsners的一种沟通水平。在这些范例中，使用了不同的视频剪辑，在这些视频剪辑中，演员说话和打手势。这些视频已在第一个资助期内设计、验证并用于SZ患者。延长第一个资助期，预计将产生特定于障碍和症状的影响以及非特定影响。在分类诊断组中，我们预计1)阴性综合征与知觉脑区域的激活减少相关，2)无组织综合征与颞叶和前扣带回(ACC)活动相关，3)偏执综合征与ACC、后扣带皮质和双侧临时顶区的社会线索解释相关。抑郁和躁狂综合征预计与颞叶和边缘激活有关。该项目是第一个资助期的重要延长，因为它1)验证了SZ患者先前的证据，它允许推断2)特定诊断(SZ、MD、BD)，3)诊断不特定以及4)关于社交沟通功能的特定综合征结果。这一结果将为最相关的精神障碍和临床症状提供新的病理生理学见解。

Patients with schizophrenia (SZ), major depression (MD) and bipolar disorder (BD) are characterized by impairments in multimodal semantic and socio-cognitive communicative processes. The disorder- and syndrome-specific and trans-diagnostic value of these dysfunctions and related neural correlates are unknown. In the proposed project three important levels of social communicative functioning (see Ochsner, 2008; Biol. Psychiatry) will be investigated using fMRI: 1) The comprehension of non-verbal information, 2) the recognition of social-affective information and 3) the interpretation of social cues.In the first funding period (DFG GZ: Ki 588/6-1), in patients with schizophrenia we could show that the paranoid, disorganized and negative syndrome was specifically associated with activation in perceptual and social-emotional brain regions, differentially for Ochsners three constructs. Until to date, all data have been acquired and analysed. Nine peer-reviewed research articles have already been published and seven additional publications are currently in preparation. Four bachelor- and two masters theses have been completed. A. Nagels, who worked as PostDoc in the project could finish his Habilitation and principal investigator B. Straube was appointed DFG Heisenberg-Professor.In the proposed project, 60 patients with DSM IV SZ, MD, BD and healthy control subjects will be included. By means of SAPS / SANS, HAMD and YMRS a syndromal characterisation will be performed (paranoid, disorganized, negative, manic, depressed). The subjects will be examined with three fMRI paradigms, each of which reflects one of Ochsners communication levels. In the paradigms different video clips, in which an actor speaks and gesticulates, are used. The videos have been designed, validated and used in patients with SZ during the first funding period.Extending the first funding period, disorder- and syndrome-specific and disorder-unspecific effects are expected. Across the categorical diagnostic groups we expect that 1) the negative syndrome correlates with reduced activation in perceptual brain regions, that 2) the disorganised syndrome correlates with temporal lobe and anterior cingulate cortex (ACC) activity and 3) the paranoid syndrome correlates during interpretation of social cues with ACC, posterior cingulate cortex and bilateral temporo-parietal regions. The depressive and manic syndrome are expected to be associated with temporal and limbic activations.This project is an important extension of the first funding period, since it 1) validates prior evidence for patients with SZ, it allows to infer 2) diagnosis specific (SZ, MD, BD), 3) diagnosis unspecific and 4) syndrome specific outcomes regarding social-communicative functioning. The results will provide a new pathophysiological insight onto the most relevant mental disorders and clinical syndromes.