The Chemistry of Fungal Antagonism and Defense

本研究的重点将是测试提取物的固体基质发酵培养物的抗真菌活性对黄曲霉，轮枝镰刀菌和农业上重要的昆虫，草地贪夜蛾。 代谢物将通过色谱法分离，使用光谱技术鉴定，并使用既定方案检测生物活性。 该项目的结果将有助于确定生态学原理是否可以成为发现新的和潜在有用的生物活性天然产品的有用指南。有了这个奖项，有机和大分子化学计划正在支持詹姆斯B博士的研究。爱荷华州大学化学系的Gloer说。 沿着他的合作者，帕特里克F。作者声明：Donald T.威克洛，都是美国农业部，教授Gloer将集中他的研究对真菌寄生/真菌寄生真菌的化学研究，攻击和殖民的重要长寿的生理结构，由其他真菌在自然界中。 该项目的中心假设是，真菌殖民者的入侵经常涉及对宿主的侵袭，因此，这些殖民者可能是有价值的，未被探索的抗真菌剂来源。 这项工作对本科生和研究生的教学以及制药和农业行业都有更广泛的影响。

The focus of this research will be to test extracts from solid-substrate fermentation cultures for antifungal activity against Aspergillus flavus, Fusarium verticillioides and an agriculturally important insect, Spodoptera frugiperda. Metabolites will be isolated by chromatographic methods, identified using spectroscopic techniques and tested for biological activity using established protocols. Results from the project will help to determine whether ecological rationale can be a useful guide to the discovery of new and potentially useful bioactive natural products.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James B. Gloer of the Department of Chemistry at the University of Iowa. Along with his collaborators, Drs. Patrick F. Dowd and Donald T. Wicklow, both of the United States Department of Agriculture, Professor Gloer will focus his research on the chemical study of mycoparasitic/fungicolous fungi that attack and colonize important long-lived physiological structures by other fungi in nature. The central hypothesis of the project is that invasion by fungal colonists frequently involves antibiosis toward the host, and therefore, such colonists may be valuable, underexplored sources of antifungal agents. The work has broader impacts in the teaching of both undergraduate and graduate students and for the pharmaceutical and agricultural industries.