GGDEF-EAL Circuitry of Vibrio Parahaemolyticus

海洋细菌副溶血性弧菌适应于表面的公共生活。当生长在表面或粘性层上时，这种有机体会诱导一个巨大的基因系统，并分化为沼泽细胞。分化允许在表面上移动和定居。这项工作的长期重点是阐明调控网络，使细菌能够在表面上发展为多细胞群落。这种类型的定居称为生物膜形成，结果是对环境侮辱的抵抗力增强，以及降解能力增强。因此，微生物与表面的相互作用对生物污损等环境问题具有重大影响。副溶血弧菌是研究细菌表面适应的良好模式生物。这个项目将调查细菌如何感知、整合和响应环境中的多种信号。在更广泛的影响方面，提出了一项基因发现计划，通过允许本科生直接参与研究过程，将教学和研究结合起来。

The marine bacterium Vibrio parahaemolyticus is adapted to communal life on surfaces. When grown on a surface or in a viscous layer, the organism induces a large gene system and differentiates to a swarmer cell. Differentiation allows movement over and colonization of surfaces. The long-term focus of this work is to elucidate the regulatory networks than enable bacteria to develop as multicellular communities on surfaces. This type of colonization, known as biofilm formation, results in heightened resistance to environmental insult as well as increased degradative capabilities. Thus, microbial interactions with surfaces have significant implications with respect to environmental issues such as biofouling. V. parahaemolyticus is an excellent model organism for studying surface adaptation by bacteria. This project will investigate how bacteria sense, integrate and respond to multiple signals in their environment. With respect to broader impact, a gene discovery plan is proposed that will integrate teaching and research by allowing undergraduate students to directly participate in the research process.