DNA-Templated Assembly of Multichromophore Aggregates and Nanoparticle Wires

本研究的重点是利用DNA的小凹槽作为螺旋组装合成的模板。花青素的螺旋聚集体将被组装，导致右手螺旋形态和具有有趣光学性质的材料。染料上的中性取代基会在聚集体内产生蓝移吸收光谱和猝灭荧光，而阳离子取代将产生具有红移吸收光谱和强荧光的聚集体。聚集体结构将通过光学和高分辨率核磁共振光谱进行表征。次要的凹槽结合配体也将用于将金纳米颗粒与DNA非共价连接。通过使用重复的DNA序列，多个纳米颗粒将沿着DNA以线性方式组装，有效地创建一个一维阵列或线。银沉积可用于沿dna -金模板形成连续的银金属线。通过这个奖项，有机和大分子化学项目支持卡内基梅隆大学化学系Bruce A. Armitage博士的研究。阿米蒂奇博士将把他的工作重点放在利用DNA作为合成有机染料和无机纳米粒子螺旋组装的支架上。合成的材料可能分别具有非线性光学特性或提供导电线。该项目还为本科生和研究生的跨学科培训提供了一个极好的场所，该项目在包括代表性不足的少数民族学生方面非常成功。

The focus of this research involves the use of the minor groove of DNA as a template for the synthesis of helical assemblies. Helical aggregates of cyanines will be assembled, leading to right-handed helical morphology and materials with interesting optical properties. Neutral substituents on the dye will afford blue-shifted absorption spectra and quenched fluorescence within the aggregate while cationic substitution will yield aggregates with red-shifted absorption spectra and intense fluorescence. The aggregate structures will be characterized by optical and high-resolution NMR spectroscopies. Minor groove binding ligands will also be used to noncovalently link gold nanoparticles to DNA. By using repetitive DNA sequences, multiple nanoparticles will be assembled in a linear fashion along the DNA, effectively creating a 1-D array, or wire. Silver deposition can be used to form a continuous wire of silver metal along the DNA-gold template.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Bruce A. Armitage of the Department of Chemistry at Carnegie Mellon University. Dr. Armitage will focus his work on using DNA as a scaffold for the synthesis of helical assemblies of organic dyes and inorganic nanoparticles. The resultant materials could have nonlinear optical properties or afford conductive wires, respectively. The project also provides an excellent venue for the interdisciplinary training of undergraduate and graduate students and the project has been very successful at including underrepresented minority students.