Self-Assembled Organic Nanotubes from Cyclic Ureas

本研究的重点是合成和研究一系列由刚性间隔基连接的脲基团组成的大环化合物。 环脲单体之间的氢键相互作用驱动它们自组装成含有相当大的均匀管状通道的管状结构。 一些分析，生物化学和物理化学方法将被用来评估这些组装纳米管的成功。 寻求具有管状通道的材料作为传感器、定向反应的模板以及在离子和小分子传输系统中的应用。 有了这个新的奖项，有机和高分子化学计划是支持化学和生物化学系的琳达清水博士的研究和教育工作在南卡罗来纳州，哥伦比亚，在那里她是一个研究助理教授。 Shimizu博士将把她的研究重点放在管状组件上，这些组件最近被证明具有抗菌性能。 在该计划中培训的本科生和研究生将获得广泛的多学科背景，使他们能够从事广泛的科学事业。 该奖项还支持化学推广计划的加强和延续，该计划促进K-12学生和教师以及熟练的科学研究人员之间的互动。

The focus of this research is the synthesis and study of a series of macrocycles that consist of urea groups linked by rigid spacers. The hydrogen bonding interactions between the cyclic urea monomers drives their self-assembly into tubular structures that contain sizeable homogeneous tubular channels. A number of analytical, biochemical and physical chemistry methods will be used to evaluate the success of these assembled nanotubes. Materials with tubular channels are sought for applications as sensors, templates for directed reactions, and in ion and small molecule transport systems. With this new award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Linda Shimizu of the Department of Chemistry and Biochemistry at the University of South Carolina, Columbia, where she is a Research Assistant Professor. Dr. Shimizu will focus her research on tubular assemblies, which have recently been shown to have antibacterial properties. Undergraduate and graduate students trained in this program will receive a broad multidisciplinary background that will empower them to pursue a wide range of scientific careers. This award also supports the enhancement and continuation of the chemistry outreach program that fosters interactions between K-12 students and teachers and skilled scientific researchers.