Functional Nanotubes from Self-Assembled Bis-Urea Macrocycles
自组装双脲大环化合物的功能纳米管
基本信息
- 批准号:1904386
- 负责人:
- 金额:$ 46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2023-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Nature employs self-assembly approaches to control the size and shape of biological structures for performing specific functions. Examples include protein channels and enzymes. A protein channel is formed by a protein that folds into a hollow tubular structure and spans across a membrane to allow passage of small molecules or ions from one side of a membrane to the other side through the channel. An enzyme is a protein that folds into a 3-dimensional structure to create a pocket of specific size and shape for binding and converting target molecules into desired chemical products. Inspired by Nature, Professor Linda Shimizu of the University of South Carolina makes small donut-shaped molecules that assemble in high fidelity into straw like structures called nanotubes. These nanotubes have tiny 1-dimensional channels of less than a nanometer (about 1/1000 times of the width of a strand of hair) in diameter. The Shimizu group conducts research to understand how gases and small molecules are organized and move through these tiny channels. Her research group also uses these nanotubes to restrict how molecules in these channels are oriented with respect to one another, which alters how these trapped guests can react. Fundamental knowledge to be gained from this research could have important implications in separation technologies, flow reactors and the development of new synthetic methods. The broad research approach provides a challenging and interdisciplinary environment to train a diverse group of graduate students as well as provides first research experiences for undergraduates and high school students. In addition, this award supports a chemistry outreach program that broadly promotes public interest in science by bringing chemists into South Carolina K-12 classrooms of high minority enrollment middle schools and high schools. These school visits are intended to showcase the scientific method, highlight cutting edge research, and foster interest in chemistry and in the natural sciences.Work in Professor Linda Shimizu's laboratory, supported by the Macromolecular, Supramolecular and Nanochemistry Program at the National Science Foundation, utilizes the controlled assembly of bis-urea macrocycles to afford functional tubular assemblies to probe fundamental questions. This research investigates structure-property relationship of macrocycles and linear analogues that contain triphenylamines, benzophenones, and other organic triplet sensitizers. After UV-irradiation, these assemblies form radicals within the walls of the nanotubes. The quantity, persistence and properties of these radicals are related to their structure and organization. In this project, the Shimizu group 1) studies the assemblies to understand the origin of the radical stability; 2) probes diffusion within the nanochannels; 3) evaluates how radicals in the channel walls interact with guests encapsulated within the channels; 4) evaluates the assemblies of triplet sensitizers in oxygenated solutions to determine their efficiency at forming reactive oxygen species; and 5) studies the ability of the nanoreactors to facilitate photooxidations, photocycloadditions and photopolymerization reactions in solution. The knowledge acquired should lead to new predictive tools to determine when persistent radicals will form as well as afford a better understanding of the effects of confinement on reactivity. These results should lead to an increase in structural diversity of organic radicals, which are of interest as molecular magnets, as probes in biological systems, for polarizing agents and as radical initiators for polymerization.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
大自然采用自组装方法来控制生物结构的大小和形状,以执行特定的功能。 例子包括蛋白质通道和酶。 蛋白质通道由折叠成中空管状结构并跨越膜的蛋白质形成,以允许小分子或离子通过通道从膜的一侧流到另一侧。 酶是一种蛋白质,可折叠成 3 维结构,形成特定大小和形状的口袋,用于结合目标分子并将其转化为所需的化学产品。 受到大自然的启发,南卡罗来纳大学的 Linda Shimizu 教授制造出了甜甜圈形状的小分子,这些分子以高保真度组装成稻草状结构,称为纳米管。这些纳米管具有直径小于一纳米(大约是一根头发宽度的 1/1000 倍)的微小一维通道。 清水小组进行研究,以了解气体和小分子如何组织并通过这些微小通道移动。她的研究小组还使用这些纳米管来限制这些通道中的分子相对于彼此的方向,从而改变这些被困客人的反应方式。 从这项研究中获得的基础知识可能对分离技术、流动反应器和新合成方法的开发产生重要影响。广泛的研究方法提供了一个具有挑战性的跨学科环境来培养多元化的研究生群体,并为本科生和高中生提供首次研究经验。 此外,该奖项还支持一项化学推广计划,该计划通过将化学家引入南卡罗来纳州少数族裔入学率较高的中学和高中的 K-12 教室来广泛促进公众对科学的兴趣。这些学校访问旨在展示科学方法,突出前沿研究,并培养对化学和自然科学的兴趣。在美国国家科学基金会大分子、超分子和纳米化学项目的支持下,清水琳达教授实验室的工作利用双脲大环化合物的受控组装来提供功能性管状组件来探测基本原理 问题。本研究研究了包含三苯胺、二苯甲酮和其他有机三重态敏化剂的大环化合物和线性类似物的结构-性质关系。紫外线照射后,这些组件在纳米管壁内形成自由基。 这些自由基的数量、持久性和性质与其结构和组织有关。 在这个项目中,清水小组1)研究组件以了解自由基稳定性的起源; 2) 探测纳米通道内的扩散; 3) 评估通道壁中的自由基如何与通道内封装的客体相互作用; 4) 评估三线态敏化剂在含氧溶液中的组装以确定其形成活性氧的效率; 5) 研究纳米反应器促进溶液中光氧化、光环加成和光聚合反应的能力。所获得的知识应该会带来新的预测工具,以确定持久性自由基何时形成,并更好地理解限制对反应性的影响。 这些结果应该会导致有机自由基结构多样性的增加,有机自由基作为分子磁体、生物系统中的探针、极化剂和聚合自由基引发剂而受到关注。该奖项反映了 NSF 的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Anti‐kooperative Selbstorganisation mit aufrechterhaltener Emission reguliert durch konformationelle und sterische Effekte
反合作自组织,通过信息和保密效应对排放进行监管
- DOI:10.1002/ange.202200390
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Helmers, Ingo;Hossain, Muhammad Saddam;Bäumer, Nils;Wesarg, Paul;Soberats, Bartolome;Shimizu, Linda S.;Fernández, Gustavo
- 通讯作者:Fernández, Gustavo
Guest Inclusion Modulates Concentration and Persistence of Photogenerated Radicals in Assembled Triphenylamine Macrocycles
- DOI:10.1021/jacs.9b11518
- 发表时间:2020-01-08
- 期刊:
- 影响因子:15
- 作者:Sindt, Ammon J.;DeHaven, Baillie A.;Shimizu, Linda S.
- 通讯作者:Shimizu, Linda S.
Structure–property investigations in urea tethered iodinated triphenylamines
尿素束缚的碘化三苯胺的结构和性质研究
- DOI:10.1039/d2cp01856j
- 发表时间:2022
- 期刊:
- 影响因子:3.3
- 作者:Hossain, Muhammad Saddam;Ahmed, Fiaz;Karakalos, Stavros G.;Smith, Mark D.;Pant, Namrata;Garashchuk, Sophya;Greytak, Andrew B.;Docampo, Pablo;Shimizu, Linda S.
- 通讯作者:Shimizu, Linda S.
Multi-dimensional copper(I) and silver (I) coordination polymers assembled with a pyridyl bis-urea macrocyclic ligand
- DOI:10.1016/j.poly.2021.115170
- 发表时间:2021-06
- 期刊:
- 影响因子:2.6
- 作者:Bozumeh Som;Mark D. Smith;Linda S. Shimizu
- 通讯作者:Bozumeh Som;Mark D. Smith;Linda S. Shimizu
Selective host–guest chemistry, self-assembly and conformational preferences of m -xylene macrocycles probed by ion-mobility spectrometry mass spectrometry
通过离子淌度质谱法探测间二甲苯大环的选择性主客体化学、自组装和构象偏好
- DOI:10.1039/c9cp06938k
- 发表时间:2020
- 期刊:
- 影响因子:3.3
- 作者:Link, Benjamin A.;Sindt, Ammon J.;Shimizu, Linda S.;Do, Thanh D.
- 通讯作者:Do, Thanh D.
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Linda Shimizu其他文献
Linda Shimizu的其他文献
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{{ truncateString('Linda Shimizu', 18)}}的其他基金
Functional nanotubes from self-assembling bis-urea macrocycles
自组装双脲大环化合物的功能性纳米管
- 批准号:
2203830 - 财政年份:2022
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
Functional Organic Nanotubes from Self-Assembled Bis-Urea Macrocycles
自组装双脲大环化合物制备功能性有机纳米管
- 批准号:
1608874 - 财政年份:2016
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
Self-assembled organic nanotubes from cyclic ureas
环状脲自组装有机纳米管
- 批准号:
1305136 - 财政年份:2013
- 资助金额:
$ 46万 - 项目类别:
Continuing Grant
Self-Assembled Organic Nanotubes from Cyclic Ureas
环脲自组装有机纳米管
- 批准号:
1012298 - 财政年份:2010
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
Self-assembled porous materials from cyclic ureas
环状脲自组装多孔材料
- 批准号:
0718171 - 财政年份:2007
- 资助金额:
$ 46万 - 项目类别:
Continuing Grant
Self-Assembled Organic Nanotubes from Cyclic Ureas
环脲自组装有机纳米管
- 批准号:
0316424 - 财政年份:2003
- 资助金额:
$ 46万 - 项目类别:
Standard Grant
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