Engineering Research Equipment: Ultrafast Laser System for Microscale Radiation Transport Studies

一项购买飞秒钛宝石激光系统的合同已经授予。这些设备将用于支持针对新兴纳米技术和生物成像应用的创新研究。具体地说，所要求的设备对于拟议的以下实验是必要的：开发具有时间对数斜率分析的地下成像方法，用于非侵入性检测小型乳腺肿瘤；双光子荧光显微镜系统，用于研究药物输送和皮肤中的氧化应激；以及纳米级传感系统，用于时间分辨检测纳米实体在表面的吸附或附着。这种地下成像方法是独创的，不需要复杂的反设计。这项研究的目的是实现漫反射光学断层扫描的实时临床应用。拟议研究的广泛影响包括促进罗格斯大学的跨学科研究，以及发展私营部门在包括生物技术在内的几个新兴领域的能力。激光系统将加强与贝尔实验室建立的合作安排。该设备还将非常有助于对研究生进行最先进的超快激光系统的操作和应用方面的培训，并向本科生介绍跨学科的研究课题。它也是罗格斯大学研究基础设施的宝贵补充。

An award has been made toward the purchase of a femtosecond Ti:sapphire laser system. The equipment will be utilized in support of innovative research addressing emerging nanotechnology and bioimaging applications. Specifically, the requested equipment is necessary for the proposed experiments in developing a subsurface imaging method with temporal log-slope analysis for noninvasive detection of small breast tumors, a two-photon fluorescence microscopy system for investigation of drug delivery and oxidative stress in skins, and a nanoscale sensing system for time-resolved detection of adsorption or attachment of nanoscopic entities to a surface. The subsurface imaging method is original and does not require complicated inverse design. The study is aimed at enabling real time clinical use of diffuse optical tomography. The broad impacts of the proposed research include a boost to interdisciplinary research at Rutgers and the development of capabilities of the PI in several emerging areas, including biotechnology. The laser system will enhance a collaborative arrangement that has been established with Bell Labs. The equipment will also be very useful for the training of graduate students in the operation and applications of state-of-the-art ultrafast laser systems, and for introducing undergraduate students to interdisciplinary topics of research. It is also a valuable addition to the research infrastructure at Rutgers University.