A high-speed network connection for genomics research

该项目建议建立一个从基因组研究所（TIGR）到马里兰州大学公园的MidAtlantic Crossroads GigaPoP（MAX），然后到Abilene网络的暗光纤高性能连接。光纤将通过FiberGate，Inc.租赁。并且将提供高性能和冗余。此外，Abilene/Internet 2连接将与位于TIGR半径一公里范围内的三个附属组织共享。其中包括联合技术中心，基因组学促进中心和生物能源替代研究所。 该提案的积极方面包括TIGR是其测序的微生物生物体的科学数据的主要贡献者。TIGR在微生物基因组测序方面的工作帮助了国土防御计划，并支持了对生物恐怖活动的调查。TIGR已经对炭疽细菌进行了测序，并对菌株之间的遗传差异进行了编目。 这种连接将进一步促进这项工作。高性能连接将增加科学数据的交换，并实现潜在的新生物信息学应用。 TIGR已经建立了许多研究应用程序，被世界各地的科学家用来进行基因组学研究。该连接将支持涉及美国各地合作者的基于基因组学的分析的几项主要举措：1。努力建立一个关于炭疽杆菌（炭疽病的病原体）基因变异的综合公共数据库; 2.美国国家科学基金会的生命之树项目，以及多机构的努力，以测序和研究代表进化树的许多不同分支的物种的基因组;3. TIGR与其他五所大学和实验室之间的大规模合作，在基因组学规模上将基因与功能联系起来，以促进对心脏，肺，血液和睡眠功能和疾病的生理和病理生理机制的研究;以及4.通过网络数据库和向其他公共档案馆提交资料，与科学界分享所有基因组学数据的工作正在进行，而且越来越多。

This project proposes to establish a dark fiber high-performance connection from the Institute for Genomic Research (TIGR) to the MidAtlantic Crossroads GigaPoP (MAX) in College Park, MD and then to the Abilene network. The fiber will be leased through FiberGate, Inc. and will provide both high performance and redundancy. Additionally, the Abilene/Internet2 connection will be shared with three affiliate organizations located within a one-kilometer radius of TIGR. These include the Joint Technology Center, The Center for the Advancement of Genomics and the Institute for Biological Energy Alternatives. Positive aspects of this proposal includeTIGR is a major contributor of scientific data on the microbial organisms that it sequences. TIGR's work in sequencing microbial genomes has aided homeland defense initiatives and supported investigations into bio-terrorist activities. TIGR has sequenced the anthrax bacterium and has been cataloging genetic differences between strains. This connection will further enable this work.A high-performance connection will enable an increased exchange of scientific data and enable potential new bioinformatics applications. TIGR has built numerous research applications that are used by scientist around the world to conduct genomics research. The connection will support several major initiatives for genomics-based analysis involving collaborators across the United States:1. an effort to build a comprehensive public database of genetic variation in the bacterium Bacillus anthracis, the causative agent of anthrax; 2. the NSF Tree of Life project, and multi-institutional effort to sequence and study the genomes of species representing many divergent branches of the evolutionary tree;3. a large-scale collaboration between TIGR and five other universities and laboratories to link genes to function on a genomics scale in order to facilitate investigations in physiological and pathophysiological mechanisms underlying heart, lung, blood, and sleep function and disease; and 4. ongoing and growing effort to share all genomics data with the scientific community, through web-based databases and through submissions to other public archives.