CAREER:Transition-Metal Catalyzed Cycloaddition Reactions

Janis Louie教授正在探索新的过渡金属催化路线，以使用二氧化碳作为有机合成中的试剂。镍催化的二炔与二氧化碳的[2 + 2 + 2]环加成的机理细节将被阐明，为具有更高反应活性和扩展底物范围的第二代催化剂的设计和合成提供输入。环加成区域选择性将与各种不同取代的不对称二炔进行评估，一般的方法将被应用到一个代表性的吡喃酮天然产物，tetillapyrone的合成。路易教授将开发一个本科生荣誉有机化学课程，旨在提高积极性高的学生的本科经验的质量，并将在犹他州的访问程序的大学内实施推广计划，通过这个奖学金和指导计划，提高年轻女科学家的机会。有机和高分子化学项目支持犹他州大学化学系Janis Louie教授的教学和研究项目。路易教授正在开发使用二氧化碳的新方法，二氧化碳是一种廉价，安全（除了其作为温室气体的作用）和丰富的化合物，用于合成复杂的有机分子。她的研究正在导致独特的反应化学的发展，这将是在显示重要的化学或生物学特性的有机分子的建设的普遍适用性。路易教授还开发了一个本科生荣誉有机化学课程，旨在提高积极性高的学生的本科生体验的质量，并将在犹他州的访问程序的大学内实施推广计划，通过这个奖学金和指导计划，提高年轻女科学家的机会。

Professor Janis Louie is exploring new transition metal catalyzed routes for the use of carbon dioxide as a reagent in organic synthesis. Mechanistic details of the nickel catalyzed [2+2+2] cycloaddition of diynes with carbon dioxide will be elucidated, providing input for the design and synthesis of second generation catalysts with higher reactivities and expanded substrate scope. Cycloaddition regioselectivity will be evaluated with a variety of differentially substituted asymmetric diynes, and the general methodology will be applied to the synthesis of a representative pyrone natural product, tetillapyrone. Professor Louie will develop an undergraduate honors organic chemistry program, designed to enhance the quality of the undergraduate experience for highly motivated students, and will also implement an outreach program within the University of Utah's ACCESS program, enhancing the opportunities afforded young women scientists through this scholarship and mentoring program.With this CAREER award, the Organic and Macromolecular Chemistry Program supports the teaching and research program of Professor Janis Louie, of the Department of Chemistry at the University of Utah. Professor Louie is developing novel methods for using carbon dioxide, an inexpensive, safe (except with respect to its role as a greenhouse gas) and abundantly available compound, for the synthesis of complex organic molecules. Her studies are leading to the development of unique reaction chemistry that will be of general applicability in the construction of organic molecules displaying important chemical or biological properties. Professor Louie is also developing an undergraduate honors organic chemistry program, designed to enhance the quality of the undergraduate experience for highly motivated students, and will also implement an outreach program within the University of Utah's ACCESS program, enhancing the opportunities afforded young women scientists through this scholarship and mentoring program.