ACT/SGER: Extremely Sensitive Fluorescent Detection of Organophosphate Nerve Agents

特拉华大学的尼尔·宗德罗教授正在开发一种基于荧光的设备，用于检测微量的有机磷神经毒剂。这些试剂，如果存在，将与乙酰胆碱酯酶反应，检测将直接或通过荧光检测胆碱酯酶活性。由于它应该可以检测到低于致死量，该装置应该有助于在恐怖袭击发生之前预防恐怖袭击。研究生和本科生都将参与该项目。该奖项由美国国家科学基金会和情报界共同支持。数学和物理科学理事会的反恐方法项目支持基础研究和劳动力发展方面的新概念，这些新概念有可能为国家安全做出贡献。

Professor Neal Zondlo of the University of Delaware is developing a fluorescence-based device for the detection of trace quantities of organophosphate nerve agents. These agents, if present, will react with the acetylcholinesterase enzyme and detection will be made either directly or via fluorescent detection of cholinesterase activity. Since it should be possible to detect sublethal amounts, the device should be helpful in preventing terrorist attacks before they occur. Both graduate and undergraduate students will participate in the project.This award is supported jointly by the NSF and the Intelligence Community. The Approaches to Combat Terrorism Program in the Directorate for Mathematics and Physical Sciences supports new concepts in basic research and workforce development with the potential to contribute to national security.