Titanium catalyzed multi-component coupling strategies based on hydroamination of alkynes

这一无机化学、生物无机化学和金属有机化学项目的奖项支持了密歇根州立大学的亚伦·奥多姆教授的研究，他探索了基于吡咯基的配体在早期过渡金属催化中的开发和阐述。奥多姆教授将通过对新型钛基催化剂的研究，研究碳-氮键形成反应的形成，特别是在杂环合成中。通过阐明关键中间体的结构特征和电子结构以了解影响金属-配体多带反应的因素，将进一步开发氢胺化催化剂。这项研究将推进吡咯、吲哚和喹啉等杂环骨架的有机转化所需的化学，这些杂环骨架在包括药物在内的大多数精细化学品的发展中起着重要的作用。开发新的反应化学和形成C-N键的催化剂是改进各种化合物合成方法的关键一步，如吡咯、吲哚和喹啉，其中许多是重要的特种和药物化合物。这项研究将允许从简单的起始原料生成相对高分子复杂性的有机化合物。研究生、本科生和博士后助理将在最前沿的无机化学课程中接受合成方法学和金属络合物电子结构研究方面的出色培训。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports Professor Aaron Odom of Michigan State University for his research exploring the development and elaboration of pyrrolyl-based ligands in early transition metal-based catalysis. Prof. Odom will investigate the formation of C-N bond forming reactions, especially in the synthesis of heterocycles, through the investigation of new titanium-based catalysts. The development of hydroamination catalysts will be furthered by the elucidation of the structural features and electronic structures of key intermediates to understand the factors governing metal-ligand multiple band reactivity. This research will advance the chemistry needed for the organic transformations of heterocyclic frameworks such as pyrroles, indoles and quinolines that are important in the development of the majority of fine chemicals including pharmaceuticals.The development of new reaction chemistry and catalysts for C-N bond formation is a critical step to improve the methodology for the synthesis of a variety of compounds such as pyrroles, indoles and quinolines, many of which are important specialty and pharmaceutical compounds This research will allow the generation of organic compounds with relatively high molecular complexity from simple starting materials. Graduate students, undergraduate students and postdoctoral associates will receive excellent training in synthetic methodology, and the electronic structure studies of metal complexes in a forefront inorganic chemistry program.