Chemistry of secondary metabolite mediated interactions between bacteria of the Roseobacter group and other organisms (C02)

本项目将重点研究玫瑰杆菌与其他细菌和藻类的相互作用，以及介导这些相互作用的次级代谢物。它们包括信号化合物、它们的衍生物、铁载体和其他化合物，如抗生素和毒素，这些化合物要么是由玫瑰杆菌产生的，要么是与它们相互作用的生物体产生的。这项工作的重要方面是结构阐明和候选化合物的合成，以测试这些化合物的效果。特别关注的是最小原心藻及其与玫瑰杆菌的相互作用。

This project will focus on interactions of roseobacters with other bacteria and algae and on the secondary metabolites involved in mediating these interactions. They include signaling compounds, their derivatives, siderophores and other compounds such as antibiotics and toxins, produced either by the roseobacters or the organisms they interact with. Important aspects of the work are structure elucidation and synthesis of candidate compounds to test effects of these compounds. A special focus is on the alga Prorocentrum minimum and its interaction with roseobacters.