GOALI: Scanning Probe Recognition Microscopy

扫描探针显微镜技术的家庭已经彻底改变了半导体，聚合物和纳米结构的研究，最近在生物医学的巨大影响。 扫描探针显微镜的关键功能是，通过反馈回路，检测器和压电驱动的控制组合，它可以直接调查原子到纳米尺度的现象。 由于定位和致动问题，目前的扫描探针显微镜系统没有能力可靠地返回到感兴趣的特定纳米尺度特征并与之直接相互作用。 目前的研究将增加这一重要的能力，已经强大的扫描探针显微镜家庭。我们的关键是让扫描探针显微镜系统本身能够通过识别该部位对扫描探针显微镜系统的感觉而不是通过该部位对人类操作员的外观来返回到感兴趣的特定纳米级特征。 这是一种学习驱动的方法，通过将扫描探针显微镜压电实现与在线图像处理和动态自适应学习算法相结合而成为可能。 除了高端命令之外，人类操作员被消除了;因此这种方法具有广泛实施的巨大潜力。 这种方法与扫描探针显微镜的相互作用感测能力一起工作，该扫描探针显微镜具有固有的纳米至原子分辨率。 该技术被命名为扫描探针识别显微镜。扫描探针识别显微镜的成功实施将使所有纳米技术领域的研究能力和易用性达到新的水平。 这种影响在直接进行纳米生物医学研究方面可能特别重要，因为生物学和医学的关键问题围绕着通过特定大分子与特定表面受体位点相互作用触发的调节信号级联。扫描探针识别显微镜在纳米医学中的应用结果可能是在几乎类似生命的条件下研究的纳米级生命单位的新的直接信息的革命。 扫描探针识别显微镜通过NSF GOALI计划（学术与工业联络的资助机会）共同资助。 其成功的一个关键因素是与全球领先的扫描探针显微镜系统开发商和制造商Veeco Metrology /Digital Instruments建立了战略合作伙伴关系。 该合作伙伴关系将提供一个非常直接的途径，使扫描探针识别显微镜的能力迅速提供整个纳米技术社区，并为参与研究的学生，这将使他们成为下一代纳米技术研究人员的领导者一个独特的机会。

The family of Scanning Probe Microscopy techniques has revolutionized studies of semiconductors, polymers and nanostructures, with recent dramatic impacts in biomedicine. The key capability of Scanning Probe Microscopy is that, through a controlled combination of feedback loops, detectors and piezoelectric actuation, it enables direct investigations of atomic to nanometer scale phenomena. Due to positioning and actuation issues, current Scanning Probe Microscopy systems do not have the power to reliably return to and directly interact with a specific nanoscale feature of interest. The present research will add this important capability to the already powerful Scanning Probe Microscope family. Our key is to give the Scanning Probe Microscope system itself the power to return to a specific nanoscale feature of interest by recognizing the way that site feels to the Scanning Probe Microscope system rather than by the way the site looks to a human operator. It is a recognition-driven and learning approach, made possible through combining Scanning Probe Microscope piezoelectric implementation with on-line image processing and dynamically adaptive learning algorithms. The human operator is eliminated except for high-end commands; therefore this approach has tremendous potential for widespread implementation. This approach works with the interaction sensing capability of a Scanning Probe Microscope, which has inherently nanometer to atomic resolution. The technique is named Scanning Probe Recognition Microscopy.Successful implementation of Scanning Probe Recognition Microscopy will bring all nanotechnology fields a new level of investigative capability and ease of use. The impact could be especially significant in enabling direct nano-biomedical investigations, since key issues in biology and medicine revolve around regulatory signaling cascades that are triggered through the interaction of specific macromolecules with specific surface receptor sites. The results of applications of Scanning Probe Recognition Microscopy in nano-medicine could be a revolution in newly available direct information from nanoscale living units investigated under nearly life-like conditions. Scanning Probe Recognition Microscopy is co-funded through the NSF GOALI program (Grant Opportunity for Academic Liaison with Industry). A key element in its success is a strategic partnership with Veeco Metrology /Digital Instruments, the leading developer and manufacturer of Scanning Probe Microscope systems world wide. The partnership will provide a very direct path to make the Scanning Probe Recognition Microscopy capability quickly available throughout the nanotechnology communities, and a unique opportunity for the students involved in the research, which will prepare them to become leaders within the next generation of nanotechnology researchers.