SGER: Bioengineering a SPM Based Nanomanipulator With Landmark Referenced Control

SGER：利用地标参考控制对基于 SPM 的纳米操纵器进行生物工程设计

• 批准号: 0225805
• 负责人: Virginia Ayres
• 金额: $ 4.66万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0225805&HistoricalAwards=false
• 关键词: SGER; Bioengineering; SPM; Based; Nanomanipulator

0228508AyresThe goal of the proposed work is to combine high-resolution Scanning Probe Microscope (SPM)-based imaging that has been achieved for biological specimens with a novel approach to SPM-based nanomanipulation to yield a significant new approach for direct nanobiological investigations. To achieve efficient and reliable manipulation in a micro/nano environment, capabilities of sensing, processing and actuation in dynamic interactions are essential. Using the proposed approach, signals that would normally be projected as an SPM image are acquired and essential information is extracted for subsequent use as the sensing component within a feedback control loop formulation. The control loop is used to accurately steer the probe's tip along a prescribed trajectory. The feedback loop formulation involves landmark recognition and dynamic pattern matching through adaptive learning. With this capability, the tip is able to return to and stay centered on a specific site by recognizing the way the site feels to the probe tip. Except for high-level commands, the human operator can be eliminated from the operation and the full potential of this instrument with inherently sub-nanometer resolution can be utilized.

拟议工作的目标是将已实现的基于高分辨率扫描探针显微镜(SPM)的生物标本成像与基于扫描探针显微镜(SPM)的纳米操纵的新方法相结合，以产生一种重要的新方法，用于直接的纳米生物学研究。为了在微纳米环境中实现高效和可靠的操作，动态交互中的传感、处理和执行能力是必不可少的。利用所提出的方法，采集通常被投影为SPM图像的信号，并提取基本信息以用于随后用作反馈控制回路公式中的传感组件。控制回路用于沿着规定的轨迹精确地操纵探头的尖端。反馈环公式包括通过自适应学习的地标识别和动态模式匹配。有了这一功能，通过识别探头尖端对该位置的感觉，尖端能够返回并保持在特定位置的中心。除了高级命令外，操作人员可以免去操作，并且可以充分利用该仪器固有的亚纳米分辨率的潜力。