Synthesis of Heterocyclic Natural Products

这项研究的重点是全合成结构独特的多环海洋苔藓虫生物碱，其基团为查特林/查特拉胺/赛可拉明。重点将放在开发创新和实用的有机合成方法上，这将对学术界和工业界的化学家有用。有了这个奖项，有机和高分子化学计划将支持宾夕法尼亚州立大学化学系Steven M.Weinreb博士的研究。Weinreb教授将专注于杂环和杂环海洋天然产物合成方法和新策略的开发。这项工作有很大潜力在制药行业产生更广泛的影响，该项目是培养研究生和博士后的绝佳场所。

The focus of this research involves the total synthesis of the structurally unique polycyclic marine bryozoan alkaloids of the chartelline/chartelamides/securamine group. A strong emphasis will be placed on developing innovative and practical methods of organic synthesis which will be of use to chemists in both academia and industry.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Steven M. Weinreb in the Department of Chemistry at Pennsylvania State University. Professor Weinreb will focus his work on development of methodology and new strategies for the synthesis of heterocycles and heterocyclic marine natural products. The work has great potential for broader impact in the pharmaceutical industry and the project serves as an excellent venue for the training of graduate students and postdoctorals.