RUI: Investigation of the Properties and Reactivities of 1,2-Diazetine Dioxides

在化学系有机动力学项目的支持下，加里W.贝里学院的布雷东将寻求扩大我们对二氮杂环丁烷二氧化物的知识，这是1971年发现的一类非常特殊的化合物。在发现一氧化氮具有重要的生理学意义以及二氮杂环戊二烯能释放这种简单的气体之前，它们只在少数几篇优秀的论文中受到关注。布雷东教授提议对它们的化学性质进行更详细的研究。将进行实验和计算以确定1，2-二氮杂环丁烷二氧化物的分解机理。这些化合物在生理条件下是潜在的感兴趣的一氧化氮前体。将制备具有不同应变程度的不同化合物，并确定分解的速率和热力学参数，并表征产物。NO挤出二氮杂环氧化物的机制将结合应变能对NO损失率从4元杂环的影响进行研究。结果应该是更好地理解这种反应。有机和高分子化学计划支持教授加里W。贝里学院的布雷东将承担一个精心设计的项目，重点是动力学和机制。该项目将为学生提供挑战，将提出几个层次的难度增加。该项目计划周密，可能会产生广泛有趣的结果，这将为参与现代化学研究的学生提供一个复杂的开端。一氧化氮具有重要的生理特性，调节合成前体的生产速率的能力可能具有有用的医学意义。

With the support of the Organic Dynamics Program in the Chemistry Division, Professors Gary W. Breton of Berry College will seek to expand our knowledge of the diazetine dioxides, a very specific class of compounds that was discovered in 1971. They received attention in only a few good papers until the discovery that nitric oxide was of great physiological importance and that diazetine dioxides liberate this simple gas. Professor Breton is proposing a more detailed investigation of their chemistry. Experiments and computations to determine the mechanism of decomposition of 1,2-diazetine dioxides will be carried out. These compounds are potenially interesting precursors to nitric oxide under physiological conditions. Different compounds with varying degrees of strain will be prepared and the rates and thermodynamic parameters for the decomposition will be determined and the products characterized. The mechanism of NO extrusion from diazetine dioxide will be studied in conjunction with the effect of strain energy on the rate of NO loss from the 4-membered heterocycles. The results should be a much better understanding of this reaction. The Organic and Macromolecular Chemistry Program supports Professors Gary W. Breton of Berry College who will undertake a well-designed project that has a strong focus on kinetics and mechanism. The project will provide students with challenges that will present several levels of increasing difficulty. The project is well planned and will likely produce broadly interesting results that will provide for the students involved a sophisticated initiation into modern chemical research. Nitric oxide has important physiological properties, and an ability to tune the production rates from the precursors synthesized could have useful medical implication.