Imaging genetics in schizophrenia and bipolar disorder: shared neurocognitive endophenotypes

精神分裂症和双相情感障碍在任何时候都困扰着大约506，000名澳大利亚人，并且是残疾和国家经济负担的主要原因。这项研究将描述这些疾病与两种疾病共同的特定神经认知功能障碍相关的遗传基础。这些发现对于基于基因型实施个性化药物治疗以及开发针对认知功能的治疗药物具有重要意义。这些结果也将有助于检测年轻人的病前精神病，这些人可能受益于可能阻止疾病轨迹的早期干预。

Combined, schizophrenia and bipolar disorder afflict approximately 506,000 Australians at any one time, and are leading causes of disability and national economic burden. This study will delineate genetic underpinnings for these conditions in association with specific neurocognitive dysfunctions that are common to both disorders. These findings have important implications for the implementation of personalised pharmaceutical treatments on the basis of genotype, and the development of therapeutic agents to target cognitive function. These results will also aid detection of premorbid psychotic illness in young individuals who may benefit from early intervention that may thwart the illness trajectory.