Single Nanoparticle Optics for Sensing, Spectroscopy, and Probe Microscopy

在分析和表面化学项目的支持下，西北大学的理查德·范·杜恩教授正在研究单个金属纳米颗粒的光学性质。正在制定战略，以定制具有优化特性的颗粒，以用于超敏感的化学传感平台。光学显微镜技术和集成探针显微镜被应用于对单个颗粒进行局域表面等离子体共振(LSPR)散射光谱实验。通过反应离子刻蚀和电子束沉积，在纳米孔模板内浇注材料，制备出尺寸、形状和组成可控和定义良好的颗粒。通过表面增强拉曼散射和尖端增强拉曼光谱(TERS)测量研究单分子性质的策略也在进行中。合成和检测策略正在提高化学传感的灵敏度，并使人们能够对具有催化和细胞生物学应用潜力的局部化学反应部位有新的见解。

With the support of the Analytical and Surface Chemistry Program, Professor Richard Van Duyne of Northwestern University is investigating the optical properties of individual metal nanoparticles. Strategies are being developed for tailoring particles with optimized characteristics for use in ultra-sensitive chemical sensing platforms. Optical microscope techniques with integrated probe microscopy are applied to perform localized surface plasmon resonance (LSPR) scattering spectroscopy experiments on individual particles. Particles with controlled and well-defined size, shape and composition are prepared by casting materials inside nanowell templates through reactive ion etching and electron beam deposition. Strategies are also being pursued for the study of single molecule properties through surface enhanced Raman scattering and tip-enhanced Raman spectroscopy (TERS) measurements.The synthetic and detection strategies are improving sensitivity in chemical sensing and enabling new insights into localized chemical reaction sites with potential for application in catalysis and cell biology.