De Novo Synthesis of Oligosaccharides via Palladium Catalysis

这项研究的重点是开发不对称合成方法来生产各种低聚糖。该反应策略的中心是使用Achmatowicz重排来制备吡喃酮，并与钯催化的糖基化反应相结合。该方法将导致生产具有有趣的材料和生物学特性的新的和迄今未知的非天然低聚糖。通过这一奖项，有机和高分子化学计划支持西弗吉尼亚大学化学系的乔治·A·奥多尔蒂博士的研究。O‘Doherty博士将把工作重点放在开发不对称合成寡糖的方法学上。该方法将允许将单糖轻松地结合到低聚糖基序中，从而导致发现具有广泛功能的新结构。这项工作的更广泛影响是在材料科学领域以及制药行业。此外，该项目为本科生和研究生的培训提供了一个极好的工具。

The focus of this research involves the development of asymmetric synthetic methods for the production of a variety of oligosaccharides. The reaction strategy is centered on the use of the Achmatowicz rearrangement for the preparation of pyranones in concert with palladium-catalyzed glycosylation. The methodology will lead to the production of new and hitherto unknown unnatural oligosaccharides having interesting materials and biological properties.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. George A. O'Doherty in the Department of Chemistry at West Virginia University. Dr. O'Doherty will focus his work on developing methodology for asymmetric synthesis of oligosaccharides. The methodology will allow for the facile incorporation of simple sugars into oligosaccharide motifs thus leading to the discovery of new structures possessing a wide range of functions. The broader impact of the work is in the area of materials science as well as the pharmaceutical industry. Further, the project presents an excellent vehicle for the training of both undergraduate and graduate students.