Biophotonics: Design of Novel Implantable Brain Imaging Devices

0423076史密斯该项目的目标是设计一种新型的植入式大脑成像设备，称为IOS传感器。 基于混合GaAs NIR发射器和检测器的微尺度集成阵列，该设备将被优化以成像内在光信号（IOS），这是一种与哺乳动物皮层中的感觉和运动信息处理细节丰富的脑电活动相关的漫光学反射。IOS成像的神经生物学效用已经非常成熟，但所有以前的IOS成像都使用笨重的台式仪器，需要受试者固定，并且几乎总是麻醉。由于其体积小，IOS传感器将允许在未麻醉和自由行为的受试者中进行前所未有的皮层活动模式成像。植入式IOS传感器的应用将包括神经科学研究、神经损伤患者的假肢和药物发现。

0423076SmithThe goal of this project is the design of a novel implantable brain imaging device called an IOS sensor. Based on a microscale integrated array of intermingled GaAs NIR emitters and detectors, this device will be optimized to image the intrinsic optical signal (IOS), a diffuse optical reflectance correlate of brain electrical activity rich in detail about sensory and motor information processing in mammalian cortex. The neurobiological utility of IOS imaging is already very well established, but all previous IOS imaging has used bulky, benchtop-scale instruments that require subjects to be immobilized and, almost always, anesthetized. Because of its small size, the IOS sensor will allow unprecedented imaging of cortical activity patterns in unanaesthetized and freely behaving subjects. Applications of the implantable IOS sensor will include neuroscience research, prosthetics for neurological injury patients, and drug discovery.