SENSORS: Cell-Based Sensors that link Nanotechnology with Microfluidics

0428573 Vazquez该项目将专门开发一个原始的微流体网络（uStar），以研究多价纳米传感器对趋化性迁移的基本细胞过程的影响。该系统将使单细胞成像和纳米传感器动态的定量分析，一旦在活的成纤维细胞内实时诱导。纳米传感器将被开发为靶向细胞内蛋白，生长因子受体结合-2（GRB 2），已知启动趋化性信号级联反应时，由本项目中研究的趋化生长因子激活。

0428573VazquezThis project will specifically develop an original microfluidic network (the uStar) to study the effects of multivalent nanosensors on the fundamental cell process of chemotaxic migration. The system will enable single-cell imaging and quantitative analysis of nanosensor dynamics once inducted within viable fibroblast cells in real-time. Nanosensors will be developed to target the intracellular protein, Growth Factor Receptor Bound-2 (GRB2), known to initiate chemotaxis signaling cascades when activated by the chemoattractant growth factors studied in this project.