Realizing the Vision: Leading Edge Technologies in Biological Systems Workshop to be held in Washington, DC in September or October 2004

这项NSF拨款将为一个名为“实现愿景：生物系统的前沿技术”的基础广泛的科学研讨会提供支持，该研讨会将于2004年9月或10月在华盛顿举行。在一次非正式的圆桌讨论中确定了研讨会的潜在需求，其中包括认识到动物、微生物和植物基因组测序的速度很快，并且与单个基因和/或蛋白质功能的发现速度不匹配。此外，基因组测序不解决代谢和生理网络问题也与生物多样性有关。研讨会的目的是关注前沿和新兴技术，这些技术可以为代谢生物化学领域带来解决在可预见的未来日益重要的系统生物学问题的能力。讲习班的对象是广泛的听众，他们综合了研究生物系统的各种科学学科。它将接待18-20名各自领域（如动物、微生物和植物科学）的科学领袖，带领研讨会参与者讨论以下主题：生物系统地图；分子控制;代谢通量分析（包括单细胞分析）；生命（代谢）网络；复杂天然产物多样性的分子基础；蛋白质组学和蛋白质结构/功能；以及结构生物学和代谢工程的未来角色。具体目标包括：1)为顶尖科学家和其他有关前沿问题的相关方提供一个非正式的、深刻的对话论坛；2)通过相关科学学科的代表以及感兴趣的公众成员的直接参与，增加有关讨论和建议的信息的宣传和传播；3)提供一份报告，总结未来的需求、方向和建议，强调新兴前沿概念的重要性及其对生命（代谢）网络理解的潜在影响。更广泛的影响：该研讨会将为主要科学家和不同的参与者群体之间的非正式对话提供一个论坛。研讨会的成果将是一份带有建议的最终书面报告，以帮助了解代谢网络和系统生物学的战略路线图。该报告（连同建议）将发表在《植物化学》杂志的一个特别版上，并将与一个会议网站以及若干专业学会的网站相连。主办单位亦会拟备一份非技术报告，供公众传阅。

This NSF grant will provide support for a broadly based scientific workshop entitled: Realizing the Vision: Leading Edge Technologies in Biological Systems, and will be held in Washington, DC, during September or October of 2004. The underlying need for the workshop was identified during an informal roundtable discussion that included recognition that the rate of sequencing of animal, microbial, and plant genomes was rapid and not being matched by rates of discovery of individual gene and/or protein function. In addition, genomic sequencing does not address the metabolic and physiological network questions also related to biodiversity. The workshop is designed to focus on leading edge and emerging technologies that can bring the field of metabolic biochemistry the capability of addressing systems biology questions of increasing significance in the foreseeable future. The workshop is targeted to a broad-based audience integrating various scientific disciplines that study biological systems. It will host 18-20 scientific leaders in their respective fields (e.g., animal, microbial, and plant science) to lead workshop participants in discussions of topics such as: bioinformatics; biological systems maps; molecular gating; metabolic flux analysis (including single cell analysis); living (metabolic) networks; the molecular basis of complex natural product diversity; proteomics and protein structure/function; and the future roles of structural biology and metabolic engineering. Specific goals include to: 1) provide a forum for informal, incisive dialogue between leading scientists and other interested parties relating to leading edge issues; 2) increase outreach and dissemination of information regarding discussions and recommendations by direct involvement of representatives from related scientific disciplines as well as interested members of the public; 3) provide a report summarizing future needs, directions, and recommendations emphasizing the importance of the emergent leading edge concepts and their potential impact on the understanding of living (metabolic) networks. Broader Impact: The workshop will provide a forum for informal dialogue between leading scientists and a diverse group of participants. The product of the workshop will be a final written report with recommendations, to help inform a strategic roadmap for understanding metabolic networks and systems biology. The report (with recommendations) will be published in a special edition of the journal Phytochemistry, and will be linked to a conference website as well as to websites of a number of professional societies. Organizers will also produce a non-technical report suitable for dissemination to the general public.