Delineation of human plasma cell subsets and their bone marrow niche

体液记忆的一个重要部分是由浆细胞提供的，这些浆细胞具有明显不同的半衰期，但存在于骨髓中。与其他小组一起，我们可以确定外周血中浆细胞和浆母细胞的多样性，包括抗原特异性的。最近，在人类骨髓中鉴定出浆细胞的不同亚群。在这里，我们想探讨这些浆细胞亚群是否需要某些可溶性和不溶性的生存因子，主要关注与人骨髓细胞的潜在独特相互作用。特别是，该项目将详细描述其独特的表型，分子和功能特征，并最终研究某些浆细胞亚群解剖部位的特异性。更好地理解假设的骨髓小生境将允许影响免疫记忆形成及其维持的创新治疗方法，其可能具有广泛的临床应用，例如免疫预防和治疗。

An important part of humoral memory is provided by plasma cells with apparently distinct half-life times but residing in the bone marrow. Together with other groups we could identify a diversity of plasma cells and plasmablasts in the peripheral blood, including antigen-specific ones. More recently, distinct subsets of plasma cells were identified in the bone marrow of humans. Here we want to explore if these plasma cell subsets require certain soluble and insoluble survival factors with a main focus on a potential unique interaction with human bone marrow cells. In particular, the project will describe in detail their distinct phenotypes, molecular and functional characteristics and ultimately studying the specificities of anatomic sites of certain plasma cell subsets. Better understanding of the hypothetical bone marrow niches will permit innovative therapeutic approaches influencing immune memory formation and its maintenance which may have a wide range of clinical application, such immune prophylaxis and therapy.