Controlling Organization and Dynamics in Fluid Interfaces

密歇根州立大学的加里·布兰查德教授在分析和表面化学计划的支持下，构建了一组单层和双层流体界面，然后对其进行光学表征。杂化脂质双层结构已经被创造和表征了十多年，然而，关于膜组成和物理性质之间的关系仍然有很多未知之处。PI寻求建立一套相互关联的时间分辨荧光光谱和成像测量，以便通过荧光探针提取关于当地环境及其动态的信息。光学方法包括荧光显微镜、光漂白实验和双光子荧光实验。这项工作是与波兰科学院的Pawel Kryskinski教授合作完成的。控制合理构建的单层和双层流体界面将有利于生物技术、生物传感器的开发和人造细胞模拟的努力。这些实验为药物输送和医疗植入物等应用提供了基本基础。

Professor Gary Blanchard of Michigan State University is supported by the Analytical and Surface Chemistry program to construct and then optically characterize a set of monolayer and bilayer fluid interfaces. Hybrid lipid bilayer structures have been created and characterized for over a decade, however, there is still a great deal unknown regarding relationships between membrane composition and physical properties. The PI seeks to establish a linked set of time-resolved fluorescence spectroscopic and imaging measurements in order to extract information about the local environment and its dynamics via fluorescent probes. The optical approaches include epifluorescence microscopy, photobleaching experiments and two-photon fluorescence experiments. The work is being done in collaboration with Prof. Pawel Kryskinski of the Polish Academy of Sciences.Control over rationally constructed mono- and bi-layer fluid interfaces will benefit biotechnology, biosensor development and efforts to make artificial cell mimicks. These experiments provide fundamental underpinnings for applications such as drug delivery and medical implants.