SGER: Single-Molecule Studies of Hidden Reactions

有了这一SGER奖，有机和高分子化学项目支持了杜克大学化学系斯蒂芬·克雷格教授的工作。这项研究将使用单分子力测量来直接观察顺序双分子反应中化学键的形成和断开。将研究两步缔合-解离反应。原子力显微镜的尖端将与离开的配体一起功能化，以促进与该配体的键的断裂。以这种方式，关联步骤将成为速率确定，从而允许测量这个迄今在动力学上不可见的步骤的速率。这些势能面的单分子光谱研究有望提供重要的基础信息，这些信息将对有机、无机和生化反应的机理研究产生影响。

With this SGER award, the Organic and Macromolecular Chemistry Program supports the work of Professor Stephen Craig of the Department of Chemistry at Duke University. The research will use single molecule force measurements to directly observe the making and breaking of chemical bonds in a sequential bimolecular reaction. A two-step association - dissociation reaction will be investigated. The tip of an atomic force microscope will be functionalized with the leaving ligand facilitating the breaking of the bond to that ligand. In this way, the associative step will become rate determining allowing the rate of this hitherto kinetically invisible step to be measured. These single molecule spectroscopic studies of potential energy surfaces are expected provide important fundamental information that will impact on mechanistic investigations of organic, inorganic, and biochemical reactions.