Inter-fragmentary movement in callus formation in the early phase of fracture healing

无论有无手术干预，骨折愈合早期阶段的计算模型可以提供表征控制这一过程的生化因素的手段，并随后影响成功的愈合结果。这一独特的方法结合了软组织和固定装置对骨折愈合的贡献，最终将为临床决策、植入物设计和未来的实验研究提供良好的基础。通过促进治疗优化，该项目的成果将为每年因骨折住院的150,000名澳大利亚患者创造机会，减少医疗成本、身体损伤和生产力损失。

Computational models of the early phase of bone fracture healing can provide the means to characterise the biochemical factors that control this process, and subsequently influence successful healing outcomes, with or without surgical intervention. This unique approach, incorporating soft tissue and fixation device contributions to fracture healing, will ultimately provide a sound basis for clinical decision-making, implant design and future experimental studies. Facilitating treatment optimisation, the outcomes of this project will create opportunities to reduce healthcare costs, physical impairment, and productivity losses for the 150,000 Australian patients hospitalised annually with fractures.