NER: Nanoparticle-Assisted Plasmonic Laser Nanosurgery

本提案是对纳米科学与工程倡议NSF 04-043 NER的响应。该提案描述了一项研究计划，该计划将探索一种新的高精度纳米外科方法，称为等离子体激光纳米外科。等离子体激光纳米外科是一种依靠金属纳米颗粒附近的强激光增强来烧蚀活细胞和生物体中的纳米结构的技术。当激光频率与金属纳米粒子的等离子体激元频率一致时，纳米粒子作为纳米透镜聚焦激光光场。因此，纳米粒子附近的放大电场将对这些纳米粒子所附着的生物靶标造成纳米级的光损伤。本研究的目的是证明飞秒激光纳米外科手术的可行性(分辨率/10)超过衍射极限，并且不依赖于激光的精确聚焦。

0508266Ben-YakarThis proposal was received in response to Nanoscale Science and Engineering initiative, NSF 04-043, category NER.This proposal describes a research program that will explore a new method for high precision nanosurgery called plasmonic laser nanosurgery. Plasmonic laser nanosurgery is a technique that relies on large laser field enhancement in the vicinity of metal nanoparticles to ablate nanoscale structures in live cells and organisms. When the laser frequency coincides with the plasmon frequency of metal nanoparticles, the laser field is focalized by the nanoparticles acting as nanolenses. As a result, the amplified electric field in the vicinity of nanoparticles will cause nanoscale photodamage to the biological targets that these nanoparticles are attached to.This investigation is aimed to demonstrate the viability of femtosecond laser nanosurgery (/\/10 resolution) beyond the diffraction limit and without relying on precise focusing of the laser beam.