CAREER: Plasmonic Laser Nanosurgery Using Molecularly Targeted Gold Nanoparticles

职业：使用分子靶向金纳米颗粒的等离子激光纳米手术

• 批准号: 0846868
• 负责人: Adela Ben-Yakar
• 金额: $ 40万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0846868&HistoricalAwards=false
• 关键词: CAREER; Plasmonic; Laser; Nanosurgery; Using

0846868Ben-YakarThis proposal describes a research program that will explore a new method for high precision nanosurgery of living systems called plasmonic laser nanosurgery (PLN). In PLN, nanoparticles act like "nano-lenses" by focusing the laser energy to a small, confined region near their surface creating nanoscale cuts at the locations where they are attached. By attaching nanoparticles to targeted cellular structures, regions of tissue can be illuminated with a large laser spot, vaporizing only the targeted structures with a precision of 50 nm or less, while leaving all surrounding areas undamaged. This investigation is aimed at extending the capabilities of femtosecond (fs) laser nanosurgery beyond the diffraction limit of light (ë/10 resolution) while eliminating the need for precise and time-consuming laser focusing.

本-亚卡尔：本提案描述了一项研究计划，该计划将探索一种名为等离子体激光纳米手术（PLN）的高精度生命系统纳米手术的新方法。在PLN中，纳米粒子的作用就像“纳米透镜”，通过将激光能量聚焦到靠近其表面的一个小的、受限的区域，在它们附着的地方产生纳米级的切口。通过将纳米颗粒附着在目标细胞结构上，组织区域可以用一个大的激光光斑照射，仅以50纳米或更小的精度蒸发目标结构，同时使所有周围区域不受损害。本研究旨在扩展飞秒（fs）激光纳米手术的能力，超越光的衍射极限（ë/10分辨率），同时消除对精确和耗时的激光聚焦的需要。