CAREER: Plasmonic Laser Nanosurgery Using Molecularly Targeted Gold Nanoparticles

本-雅卡这项提案描述了一项研究计划，该计划将探索一种新的高精度生命系统纳米外科方法，称为等离子体激光纳米外科(PLN)。在PLN中，纳米粒子的作用就像“纳米透镜”，将激光能量聚焦到其表面附近的一个小的受限区域，在它们附着的位置产生纳米级的切割。通过将纳米颗粒附着在目标细胞结构上，组织的区域可以用大激光光斑照射，仅以50 nm或更小的精度蒸发目标结构，而周围所有区域都不会受到损害。这项研究的目的是将飞秒激光纳米外科的能力扩展到超过光的衍射极限(分辨率为10)，同时消除对精确和耗时的激光聚焦的需要。

0846868Ben-YakarThis proposal describes a research program that will explore a new method for high precision nanosurgery of living systems called plasmonic laser nanosurgery (PLN). In PLN, nanoparticles act like "nano-lenses" by focusing the laser energy to a small, confined region near their surface creating nanoscale cuts at the locations where they are attached. By attaching nanoparticles to targeted cellular structures, regions of tissue can be illuminated with a large laser spot, vaporizing only the targeted structures with a precision of 50 nm or less, while leaving all surrounding areas undamaged. This investigation is aimed at extending the capabilities of femtosecond (fs) laser nanosurgery beyond the diffraction limit of light (ë/10 resolution) while eliminating the need for precise and time-consuming laser focusing.