Development of a Dual-Source Time-of-Flight Mass Spectrometer for Elemental and Speciation Analysis

在主要研究仪器（MRI）项目的支持下，印第安纳大学的Gary Hieftje将开发一种双源飞行时间质谱仪（TOFMS），用于元素和物种形成分析。该仪器将由配备电喷雾（ESI）和电感耦合等离子体（ICP）源的正交TOFMS组成。它将能够在两个源之间快速切换，以获得同一样品上的ESI和ICP质谱，或者使用同时漂移TOF进行同时检测，每个源都有单独的探测器。虽然该项目的主要重点是仪器开发，但它将为博士后、研究生和本科生提供现代尖端质谱技术和相关研究领域的跨学科培训机会。多源质谱的使用在生物和环境分析领域具有吸引力。此外，对不需要物理切换的多源仪器也有商业吸引力。

With support from the Major Research Instrumentation (MRI) Program, Gary Hieftje of Indiana University will develop a dual-source time-of-flight mass spectrometer (TOFMS) for elemental and speciation analysis. The instrument will consist of an orthogonal TOFMS equipped with electrospray (ESI) and inductively coupled plasma (ICP) sources. It will enable rapid switching between the two sources to obtain both ESI and ICP mass spectra on the same sample or simultaneous detection using a simultaneous drift TOF with separate detectors for each source. Although the primary focus of this project is instrument development, it will provide novel interdisciplinary training opportunities for postdoctoral fellows, graduate and undergraduate students in modern, cutting-edge mass spectrometry techniques and allied research areas. The use of multiple source mass spectrometers has appeal in the fields of biology and environmental analysis. In addition, there is commercial appeal for instruments with multiple sources that do not require physical switching.