Statistische Physik der Transkription und ihrer Regulierung

转录是基因表达的第一步。在RNA聚合酶向DNA的招募过程中，以及在它们沿着DNA移动的过程中，它都受到严格的控制。第二种类型的控制是本项目的主题，使用统计物理学的方法进行理论研究。我们引入了一个随机模型，用于RNA聚合酶运动的复杂动力学，以及同一DNA模板上许多聚合酶的流量，因为RNA聚合酶的相互作用起着重要作用，我们将使用该模型对作用于RNA聚合酶流量的控制机制进行定量理论描述。到目前为止，这种定量描述仅适用于转录起始的控制，而不适用于后期阶段的控制。此外，我们将模拟转录机制本身的浓度和活性如何被控制为细胞生长控制的一部分。

Transcription is the first step in gene expression. It is tightly controlled both during the recruitment of RNA polymerases to the DNA, and during their movement along the DNA. The second type of control is the subject of this project where it is studied theoretically using methods from statistical physics. We have introduced a stochastic model for the complex dynamics of the RNA polymerase movement – and for the traffic of many polymerases on the same DNA template, because interactions of RNA polymerases play an important role – which we will use to develop a quantitative theoretical description of the control mechanisms which act on the traffic of RNA polymerases. So far, such a quantitative description is only available for the control of the initiation of transcription, but not for control during later stages. In addition, we will model how the concentration and activity of the transcription machinery itself is controlled as part of the control of cellular growth.