CAREER: Metal-Organic Frameworks from Dipyrrin Metalloligands

无机化学、生物无机化学和金属有机化学项目的这一奖项支持加州大学圣地亚哥分校的Seth Cohen博士使用异位螯合剂来制备新的金属配体，用于构建功能化的金属-有机骨架(MOF)。将审查金属寡头复制已知MOF体系结构的能力，以确定可预测的网络形成所需的基本设计原则。初步研究表明，在某些连接基序的作用下，金属配体可以成功地重现目标MOF的拓扑结构。早期的发现还表明，可以制备利用八面体三(螯合)构筑块的手性的同手性MOF。此外，客户交换研究表明，这些MOF是健壮的，可以很容易地交换被包裹的物种。将进行研究，以调查不同对称性和连接基元的金属配体，以及所生成框架的主客体性质。最终，这项研究计划试图揭示金属配位体产生所需的MOF拓扑所需的基本设计参数。阐明这些中心参数将允许合理地修饰配位络合物，以用作具有可预测结构的功能化MOF的构建块。具有纳米级孔和通道的材料将被设计和合成。这种材料可能会在快速增长的纳米技术领域找到大量应用，它们可能在燃料电池、催化剂和传感器中发挥核心作用。利用人们对法医科学的兴趣与日俱增的机会，法医主题将被纳入化学入门课程，作为一种手段，使学生在学术生涯早期就感到兴奋和参与。来自当地法医实验室的嘉宾讲者将阐述在普通化学课程中提出的概念的适用性。加州大学圣地亚哥分校和美国禁毒署西南实验室合作项目的启动，将为本科生提供一个学习基本化学原理和方法在工作中应用的机会。这个合作项目对学术机构和政府机构都有好处，因为它为本科生参与者提供了真实的化学工作经验，同时将当地的DEA实验室与未来法医化学家的潜在来源联系起来，后者对工作要求有很好的工作知识。其他教育目标包括与大量科学界代表性较低的少数族裔的校园进行外联和联络，以及对主要是本科生机构的教育工作者进行休假访问。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports Dr. Seth Cohen at the University of California at San Diego to use heteroditopic chelators to prepare new metalloligands for the construction of functionalized metal-organic frameworks (MOFs). The ability of metalloligands to replicate known MOF architectures will be examined in order to delineate fundamental design principles required for predictable network formation. Preliminary studies show that with some linking motifs, metalloligands can successfully reproduce the topology of target MOFs. Early findings also show that homochiral MOFs can be prepared that exploit the chirality of an octahedral tris(chelate) building block. Furthermore, guest exchange studies show that these MOFs are robust and can readily exchange encapsulated species. Studies will be undertaken to investigate metalloligands of different symmetries and linking motifs, as well as the host-guest properties of the resultant frameworks. Ultimately, this research program seeks to reveal the essential design parameters for a metalloligand needed to generate a desired MOF topology. Elucidating these central parameters will allow for the rational modification of coordination complexes for use as building blocks in functionalized MOFs with a predictable structure.Materials that possess nanoscale pores and channels will be designed and synthesized. Such materials may find a host of applications in the rapidly growing field of nanotechnology, where they may play central roles in fuel cells, catalysts, and sensors. Capitalizing on the increased interest in the subject of forensic sciences, forensic themes will be incorporated into introductory chemistry courses as a means to excite and engage students early in their academic career. Guest speakers from local forensic laboratories will illustrate the applicability of the concepts being presented in general chemistry courses. The commencement of a co-op program between U.C. San Diego and the Southwest Laboratory of the Drug Enforcement Administration will give undergraduate students an opportunity to learn about on-the-job applications of fundamental chemical principles and methods. This co-op program benefits both the academic and government institutions by providing a real chemistry work experience to the undergraduate participants, while simultaneously connecting the local DEA laboratory to a potential source of future forensic chemists, who have an excellent working knowledge of the job requirements. Other educational goals include outreach and liaison efforts to campuses with significant populations of underrepresented minorities in science, and sabbatical visits for educators from primarily undergraduate institutions.