New Ligands, Late Transition Metal Photochemistry, and DNA

在无机、生物无机和金属有机化学计划的支持下，普渡大学化学系的David R.McMillin教授建议开发合成方法来形成新的阳离子卟啉配体，这些配体经过优化可以插入到B-型DNA中，而不需要空间菌株。这些卟啉及其铂配合物将作为发色和发射探针用于结合研究，通过吸收光谱、发射光谱和圆二色谱研究基态和激发态DNA结合作用的空间、电子和库仑作用力。竞争性结合研究将确定对DNA发夹和四链具有选择性的体系，而开发新的发射猝灭机制将产生有关形成加合物的重要信息。这笔赠款将提供对使用新的、合理衍生的金属卟啉的主客体相互作用的更深层次的了解。董明林教授通过在南非担任访问研究员的工作，为招募代表性不足的少数族裔做出了贡献。来自南非的几名学生研究人员加入了他的研究小组，增强了美国学生的国际体验。

With the support of the Inorganic, Bioinorganic and Organometallic Chemistry Program, Professor David R. McMillin, of the Department of Chemistry at Purdue University proposes the development of synthetic methods to form new cationic porphyrin ligands that are optimized to intercalate into B-form DNA without steric strain. These porphyrins and their platinum complexes will serve as chromophoric and emissive probes for binding studies where the steric, electronic and coulombic forces of DNA binding interactions are studied in the ground and excited states via absorption and emission spectroscopies as well as circular dichroism studies. Competitive binding studies will identify systems selective for DNA hairpins and quadruplexes while exploitation of the novel emission quenching mechanisms will yield important information about the adducts formed. This grant will provide a deeper understanding of host-guest interactions using novel, rationally derived metalloporphyrins. Professor McMillin contributes to the recruitment of underrepresented minorities through his work as a Visiting Research Fellow in South Africa. Several student researchers from South Africa have joined his research group, enhancing the international experience of U.S. students.