SBIR Phase I: Automated Analysis of Body Fluid Chemistry Using MHD-Based Microfluidics

这个小型企业创新研究（SBIR）第一阶段项目提出开发一个便携式，密封，独立的芯片实验室，使用基于磁流体动力学（MHD）的微流体技术来执行体液的化学分析。这些芯片上的实验室体积小，重量轻，消耗最少的试剂和功率，并且可以预编程以自动化设备的大部分功能，例如泵送，混合，分离和检测。这种创新的MHD泵送技术将与独立的微电化学免疫测定检测方法相结合，用于开发密封的、全自动的、适应性强的实验室分析系统，用于独立和即时检测应用。快速，同时评估血液（或其他体液）中的蛋白质，脂质，激素，碳水化合物，维生素和临床药物是可行的。这种用于定量血液化学成分的快速自动检测设备的更广泛影响将允许在前往医生办公室或医院的单次旅行中确定患者的健康状况。任何必要的治疗措施都可以立即开始。具体的例子包括经常监测激素水平以诊断和控制绝经前或绝经期症状、监测妊娠健康、诊断和控制甲状腺和垂体疾病或其他激素调节系统。

This Small Business Innovation Research (SBIR)Phase I project proposes to develop a portable, sealed, self-contained laboratory-on-a-chip using magnetohydrodynamic (MHD) based microfluidic technology to perform chemical analyses of body fluids. These labs-on-a-chip are small, lightweight, consume minimal reagents and power and can be preprogrammed to automate most of the functions of the device such as pumping, mixing, separation and detection. This innovative MHD pumping technology will be integrated with a self-contained microelectrochemical immunoassay detection method for the development of a sealed, fully automated and adaptable lab analysis system for standalone and point-of-care detection applications. The rapid, simultaneous assessment of proteins, lipids, hormones, carbohydrates, vitamins and clinical drugs in blood (or other body fluids) is feasible. The broader impact of this rapid, automated detection device for quantitation of blood chemistry components would allow the health status of a patient to be determined within a single trip to the doctors office or hospital. Any necessary therapeutic measures could begin immediately. Specific examples include the frequent monitoring of hormone levels for diagnosis and control of premenopausal or menopausal symptoms, monitoring of the health of a pregnancy, diagnosis and control of thyroid and pituitary disorders or other hormone regulation systems.