Cucurbit[10]uril

有了这个新的奖项，有机和大分子化学项目支持马里兰大学化学系的Lyle D. Isaacs教授的工作。这项研究将调查在水溶液中使用最大的葫芦[n]uril （CB[10]）作为分子容器。特别是，将探索使用CB[10]作为分子伴侣来控制三聚氰胺低聚物折叠成明确定义的构象。此外，还将制备CB[10]与阳离子（金属）卟啉之间的配合物，并研究其在与合适的分子客体形成三分子配合物中的应用。CB -[10]-卟啉配合物也可作为水中氧化反应的催化剂。本项目还将研究通过引入小分子来控制阳离子杯芳烃在CB[10]中的大分子构象的变构控制的可能性。这些实验将评估葫芦烷作为现实世界分子容器应用的潜力，如药物输送。这个项目将促进各级学术学生的培训，包括一些来自代表性不足群体的学生，使他们成为跨学科的科学家。

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Lyle D. Isaacs of the Chemistry Department at the University of Maryland, College Park, MD. This research will investigate the use of cucurbit[10]uril (CB[10]), the largest cucurbit[n]uril known, as a molecular container in aqueous solution. In particular, the use of CB[10] as molecular chaperone to control the folding of melamine oligomers into well-defined conformations will be explored. In addition, complexes between CB[10] and cationic (metallo)porphyrins will be prepared and their use in forming termolecular complexes with suitable molecular guests will be investigated. The CB[10]-porphyrin complexes will also be applied as catalysts for oxidation reactions in water. This project will also investigate the possibility of allosteric control of the macromolecular conformation of cationic calixarenes inside CB[10] by the introduction of small molecules. These experiments will evaluate the potential for cucurbiturils to function as real-world molecular containers for applications such as drug delivery. This project will foster the training of students at all academic levels, including a number from underrepresented groups, as interdisciplinary scientists.