Low Valent Titanium-Mediated Organic Synthesis

本项目主要致力于低价钛介导的碳-碳键形成的机理和合成研究。 沿着羧酸酯和衍生物的Kulinkovich环丙烷化的详细机理研究，该项目将针对容易获得的杂原子取代的环丙烷的合成应用，通过利用环张力的缓解来有效地构建中等尺寸的碳环。 本课程将研究烯烃交换与碳代甲烷、乙烯基酰胺的分子内环丙烷化、硫代缩醛介导的分子内环丙烷化、乙烯基环丙醇的亲电加成以及环丙醇作为高烯醇化物的利用。韦恩州立大学化学系的Cha说。 Cha教授和他的学生将开发过渡金属介导的有机转化，这些转化既经济又易于执行。 该项目对化学和制药行业具有重要意义，因为它可能会影响有机分子的制备方式。

This project is focused on the mechanistic and synthetic studies of low valent titanium-mediated carbon-carbon bond formation. Along with detailed mechanistic studies of the Kulinkovich cyclopropanation of carboxylic esters and derivatives, the project will be directed at the synthetic application of the readily available heteroatom substituted cyclopropanes for efficient construction of medium-sized carbocycles by taking advantages of relief of ring strain. Olefin exchange vs. carbometallation, intramolecular cyclopropanation of vinylogous amides, thioacetal-mediated intramolecular cyclopropanation, electrophilic addition of vinyl cyclopropanols, and utilization of cyclopropanols as homoenolates will be investigated.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jin K. Cha of the Department of Chemistry at Wayne State University. Professor Cha and his students will be developing transition metal mediated organic transformations that are economical and easy to execute. The project is of considerable significance to the chemical and pharmaceutical industry, as it could impact how organic molecules are prepared.