Dynamics of Chiral Organolithiums: Enantiomerizations and Resolutions

有了这个新的奖项，有机和高分子化学项目支持阿肯色大学化学系罗伯特·E·高利教授的工作。这项研究将考察手性和非手性配体存在和不存在的情况下，选择的手性有机锂化合物的对映体和拆分动力学。将获得热力学和动力学数据，以便了解这些重要的活性中间体的动力学。我们将详细考察几类合成相关的手性有机硫化合物的典型例子。这些研究旨在开发一套原理，为手性有机锂在立体选择性合成中的应用奠定基础。由于立体选择性合成在药物和其他生物重要分子的合成中变得至关重要，这些研究有望有助于解决化学和生物学界面上的重要问题。这项研究将涉及国际合作，并通过本科生、研究生和博士后的直接研究经验促进学习。

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Robert E. Gawley, of the Chemistry Department at the University of Arkansas. This research will examine the enantiomerization and resolution dynamics of selected chiral organolithium compounds in the presence and absence of chiral and achiral ligands. Thermodynamic and kinetic data will be obtained in order to build an understanding of the dynamics of these important reactive intermediates. Representative examples of several classes of synthetically relevant chiral organolithiums will be examined in detail. These studies are directed toward developing a set of principles that will provide a foundation for advances in the use of chiral organolithiums in stereoselective synthesis. Since stereoselective synthesis is becoming crucial in the synthesis of pharmaceuticals and other biologically important molecules, these studies are expected to contribute to the solution of important problems at the interface of chemistry and biology. The research will involve an international collaboration and promote learning through direct research experiences for undergraduates, graduates and postdoctorals.