Conformationally Programmable Molecular Receptors

这个项目试图开发一种新的可重新编程的分子受体，在这种受体中，识别能力可以可逆地写入、保存和删除。这与大多数合成分子的静态性质形成了鲜明对比，在这些分子中，分子属性只能在合成过程中设置。这种改变和改变识别性质的能力是通过使用分子来实现的，这些分子可以采用多个室温稳定的构象，这是由于围绕C-N键的有限旋转。分子可以在客体存在的情况下进行退火，以形成互补的结构。然后，通过冷却到室温，这些可以保存为稳定的构象。保存的构象可以在没有客户的情况下通过加热来擦除，或者通过与不同的客户一起加热来重写。通过这一奖项，有机和高分子化学项目支持南卡罗来纳大学研究基金会化学系清水健教授的研究。清水教授的研究工作围绕着识别材料的开发，这种材料由于其分子性质的动态控制而具有多功能。建议的策略可以扩展到其他构象相关的性质，如溶解度、粘度和折射率。所提出的机制也与蛋白质折叠等动态生物过程有许多相似之处，可以作为这些过程的模型。

This project seeks to develop a new line of reprogrammable molecular receptors, in which recognition abilities could be reversibly written, saved, and erased. This is in contrast to the static nature of most synthetic molecules in which the molecular properties can only be set during its synthesis. This ability to alter and change recognition properties is accomplished using molecules that can adopt multiple room temperature stable conformations due to restricted rotation about C-N bonds. The molecules can be annealed in the presence of a guest to form complementary structures. These can then be saved as stable conformers by cooling to room temperature. Saved conformations can be erased by heating in the absence of guest or rewritten by heating with a different guest. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Ken D. Shimizu of the Department of Chemistry at University South Carolina Research Foundation. Professor Shimizu's research efforts revolve around the development of recognition materials that are multifunctional due to dynamic control over their molecular properties. The proposed strategy could be extended to other conformationally dependent properties, such as solubility, viscosity, and refractive index. The proposed mechanism also shares many similarities with dynamic biological processes such as protein folding and could serve as models for these.