Linking the evolutionary and bioenergetic causes of sex differences in lifespan and ageing.

长寿和衰老的生物学研究有两个重要方面：了解进化如何塑造寿命和衰老，以及基因、激素、组织和细胞在衰老过程中如何相互作用的机制研究。延长寿命和提高生活质量的干预措施有赖于在这两个领域的积极和创新的研究努力。该项目解决了为什么男性和女性的寿命不同，年龄也不同，这是进化论和机械论研究之间的桥梁，并将建设澳大利亚在这两个层面上研究老龄化的研究能力。由于人类对饮食、性、生殖和衰老的兴趣，我们预计这项研究将成为公众对科学感兴趣的展示窗口。

The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how genes, hormones, tissues and cells interact during ageing. Interventions to prolong longevity and improve quality of life depend on a vigorous and innovative research effort in both spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Because of the human interest in diet, sex, reproduction and ageing, we expect this research will be a showcase for public interest in science.