Cardiovascular Flow Synthesis - A Hybrid Systems Approach

每年有数十万患者死于心力衰竭。为了满足这一巨大的需求，有许多医疗设备正在继续开发，包括人工心脏、假心脏瓣膜和主动脉内球囊泵。所有这些设备都是在实验室开发的，最好是最少的昂贵的动物实验。为了促进心血管设备的发展和减少动物实验的数量，该项目寻求开发软件控制的精密泵，可以模拟心脏的泵动，病变动脉的阻抗或血管在吸入下的塌陷。我们将开发数学模型，使泵系统的优化，以匹配心血管流量；控制算法解决了与生理阀门关闭和泵摩擦相关的不连续问题。

AbstractHundreds of thousands of patients die from heart failure every year. To address this tremendous need, there are a number of medical devices that continue to be developed including artificial hearts, prosthetic heart valves and intra-aortic balloon pumps. All of these devices are developed in the laboratory, preferably with a minimum of costly animal experiments. To facilitate the development of cardiovascular devices and reduce the number of animal experiments, this project seeks to develop software-controlled precision pumps that can simulate a pumping heart, the impedance of a diseased artery or the collapse of a blood vessel under suction. We will develop mathematical models that enable the optimization of pumping systems to match cardiovascular flow; and control algorithms that address the issues of discontinuities associated with physiologic valve closure and pump friction.