CRIF:MU Acquisition of a Cyber Enabled Liquid Chromatograph-Mass Spectrometer

阿拉巴马大学塔斯卡卢萨分校化学系将从化学研究仪器和设施：多用户（CRIF:MU）项目中获得一台液相色谱质谱计（LC-MS）。所要求的LC-MS将促进正在进行的研究项目，包括：光合系统的辅助因子鉴定和蛋白质组学分析；铬在人体代谢中的作用及其在胰岛素敏感性和糖尿病治疗中的意义的阐明水相催化水溶性配体的开发及金属催化核苷修饰的研究用于一系列工业用途的五氟磺酰苯和氟化聚合物的制备和特性；以及金属肽和去质子化肽序列的基础和应用研究。质谱是物理和生物科学家使用的一种基本工具，通过精确测量材料和化学物质在仪器中蒸发和破碎时的质量，来识别和表征它们。液相色谱是一种纯化技术，在引入质谱仪之前将复杂的混合物分离成单独的成分。这些都是培训年轻科学家的重要工具。在接下来的几年里，超过60名学生研究人员将在他们的研究项目中使用LC-MS。这包括研究生，本科学年和暑期学生（包括UA的NSF REU项目的学生），以及参加暑期项目的高中教师。通过使用自动进样器和网络控制，位于4个或更多区域本科院校（包括两个少数民族服务机构）的教育工作者和研究人员将可以使用该仪器进行实验室课程和本科生研究。

The Chemistry Department at the University of Alabama Tuscaloosa will acquire a liquid chromatograph mass spectrometer (LC-MS) with this award from the Chemistry Research Instrumentation and Facilities: Multi User (CRIF:MU) program. The requested LC-MS will facilitate ongoing research projects including: cofactor identification and proteomic analysis of photosynthetic systems; elucidation of the role of chromium in human metabolism and its implications in insulin sensitivity and treatments of diabetes; the development of water-soluble ligands for aqueous-phase catalysis and studies of metal-catalyzed modification of nucleosides; preparation and characterization of pentafluorosulfanyl-benzenes and fluorinated polymers for use in a range of industrial applications; and fundamental and applied studies into the sequencing of metallopeptides and deprotonated peptides.Mass spectroscopy is a basic tool used by physical and biological scientists to identify and characterize materials and chemical species by accurate measurement of their mass as they are vaporized and fragmented in the instrument. Liquid chromatography is a purification technique that separates a complex mixture into individual components before introduced to the mass spectrometer. These are important tools to be used in the training of young scientists. Over 60 student researchers will use LC-MS in their research projects over the next few years. This includes graduate students, undergraduate academic year and summer students (including students from UA's NSF REU program), and high school teachers participating in summer programs. Through the use of an autosampler and cyber-control, educators and researchers located at 4 or more regional undergraduate institutions including two minority serving institutions, will have access to the instrument for the purposes of laboratory classes and undergraduate research.